Document Detail


Coronary flow reserve as an index of cardiac function in mice with cardiovascular abnormalities.
MedLine Citation:
PMID:  19963485     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mice are now commonly used as models of human cardiovascular diseases and conditions, but it is challenging to measure blood flow velocity in small vessels such as coronary arteries. Accordingly, we have developed a method using a 2 mm diameter 20 MHz pulsed Doppler probe applied to the chest of anesthetized mice to measure left main coronary blood flow velocity noninvasively. We also found that coronary flow velocity could be increased from baseline (B) to hyperemic (H) levels by changing the concentration of isoflurane gas anesthesia from 1% to 2.5% in oxygen. We used the ratio B/H to estimate coronary flow reserve (CFR) in young, adult, and old mice and in mice with obesity, atherosclerosis, pressure overload hypertrophy, and coronary artery occlusion. We found that B/H increases with age from 2.4 (young) to 3.6 (old) and is decreased to as low as 1.1 by all forms of heart and vascular disease studied. We conclude that CFR can be measured noninvasively and serially in mice as their cardiovascular systems adapt and remodel to various imposed or natural conditions, and that coronary flow reserve may be a good index of overall cardiac function in mice and potentially in man.
Authors:
Craig J Hartley; Anilkumar K Reddy; Lloyd H Michael; Mark L Entman; George E Taffet
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2009     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2009  
Date Detail:
Created Date:  2009-12-07     Completed Date:  2010-04-22     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1094-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology
Animals
Apolipoproteins E / deficiency,  genetics
Biomedical Engineering
Blood Flow Velocity / physiology
Cardiovascular Abnormalities / physiopathology*,  ultrasonography
Coronary Artery Disease / physiopathology,  ultrasonography
Coronary Circulation / physiology*
Coronary Stenosis / physiopathology,  ultrasonography
Coronary Vessels / physiopathology,  ultrasonography
Disease Models, Animal
Electrocardiography
Heart Function Tests / methods
Humans
Mice
Mice, Knockout
Ultrasonography, Doppler
Grant Support
ID/Acronym/Agency:
K25-HL73041/HL/NHLBI NIH HHS; P01-HL42550/HL/NHLBI NIH HHS; R01 HL022512/HL/NHLBI NIH HHS; R01 HL022512-33/HL/NHLBI NIH HHS; R01-AG17899/AG/NIA NIH HHS; R01-HL22512/HL/NHLBI NIH HHS; R41-HL76928/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoproteins E
Comments/Corrections

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