| Coronary flow reserve as an index of cardiac function in mice with cardiovascular abnormalities. | |
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MedLine Citation:
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PMID: 19963485 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mice are now commonly used as models of human cardiovascular diseases and conditions, but it is challenging to measure blood flow velocity in small vessels such as coronary arteries. Accordingly, we have developed a method using a 2 mm diameter 20 MHz pulsed Doppler probe applied to the chest of anesthetized mice to measure left main coronary blood flow velocity noninvasively. We also found that coronary flow velocity could be increased from baseline (B) to hyperemic (H) levels by changing the concentration of isoflurane gas anesthesia from 1% to 2.5% in oxygen. We used the ratio B/H to estimate coronary flow reserve (CFR) in young, adult, and old mice and in mice with obesity, atherosclerosis, pressure overload hypertrophy, and coronary artery occlusion. We found that B/H increases with age from 2.4 (young) to 3.6 (old) and is decreased to as low as 1.1 by all forms of heart and vascular disease studied. We conclude that CFR can be measured noninvasively and serially in mice as their cardiovascular systems adapt and remodel to various imposed or natural conditions, and that coronary flow reserve may be a good index of overall cardiac function in mice and potentially in man. |
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Authors:
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Craig J Hartley; Anilkumar K Reddy; Lloyd H Michael; Mark L Entman; George E Taffet |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference Volume: 2009 ISSN: 1557-170X ISO Abbreviation: Conf Proc IEEE Eng Med Biol Soc Publication Date: 2009 |
Date Detail:
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Created Date: 2009-12-07 Completed Date: 2010-04-22 Revised Date: 2012-05-04 |
Medline Journal Info:
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Nlm Unique ID: 101243413 Medline TA: Conf Proc IEEE Eng Med Biol Soc Country: United States |
Other Details:
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Languages: eng Pagination: 1094-7 Citation Subset: IM |
Affiliation:
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Department of Medicine, Section of Cardiovascular Sciences, Baylor College of Medicine and The Methodist DeBakey Heart & Vascular Center, Houston, TX 77030, USA. rleder@ieee.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Apolipoproteins E / deficiency, genetics Biomedical Engineering Blood Flow Velocity / physiology Cardiovascular Abnormalities / physiopathology*, ultrasonography Coronary Artery Disease / physiopathology, ultrasonography Coronary Circulation / physiology* Coronary Stenosis / physiopathology, ultrasonography Coronary Vessels / physiopathology, ultrasonography Disease Models, Animal Electrocardiography Heart Function Tests / methods Humans Mice Mice, Knockout Ultrasonography, Doppler |
| Grant Support | |
ID/Acronym/Agency:
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K25-HL73041/HL/NHLBI NIH HHS; P01-HL42550/HL/NHLBI NIH HHS; R01 HL022512/HL/NHLBI NIH HHS; R01 HL022512-33/HL/NHLBI NIH HHS; R01-AG17899/AG/NIA NIH HHS; R01-HL22512/HL/NHLBI NIH HHS; R41-HL76928/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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