| Coronary flow--pressure relationship distal to epicardial stenosis. | |
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MedLine Citation:
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PMID: 12808271 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the coronary flow velocity - pressure relationship distal to a stenosis, and to evaluate the influence of microvascular abnormalities on this relationship, coronary flow velocity and coronary pressure were measured simultaneously in 38 patients (42 vessels). The instantaneous peak coronary flow velocity was plotted against the simultaneous measured distal coronary pressure, and the slope of the relation in the phase of diastolic flow decrease was calculated as the flow - pressure slope index (FPSI) and the X-intercept of the slope was calculated as zero-flow pressure (Pzf). The slope of the curve increased from 2.0+/-2.6 to 4.5+/-4.1 (p<0.001) and the X-intercept decreased from 42+/-16 to 27+/-13 mmHg (p<0.001) after papaverine injection. After successful coronary intervention, Pzf increased from 23+/-10 to 35+/-11 (p<0.01) and FPSI decreased from 6.8+/-5.1 to 3.5+/-1.8 (p<0.05). Pzf was higher in patients with an old myocardial infarction. It is feasible to assess the relationship between coronary flow and pressure distal to a stenosis in the clinical setting, and the relationship may provide additional information regarding coronary microcirculation. Microvascular abnormalities may play an important role in the coronary flow - pressure relationship distal to stenosis. |
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Authors:
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Nobuhiro Tanaka; Kenji Takazawa; Kazuhiro Takeda; Masaru Aikawa; Naohisa Shindo; Kazutaka Amaya; Yuichi Kobori; Akira Yamashina |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 67 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-16 Completed Date: 2004-01-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 525-9 Citation Subset: IM |
Affiliation:
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The Second Department of Internal Medicine, Tokyo Medical University, Japan. n-tanaka@tokyo-med.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Blood Flow Velocity Blood Pressure Coronary Angiography Coronary Circulation* Coronary Restenosis / physiopathology Coronary Stenosis / physiopathology* Feasibility Studies Female Heart Catheterization Humans Male Microcirculation Middle Aged Myocardial Contraction Myocardial Infarction / physiopathology Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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