| Coronary flow as a determinant of c-myc and c-fos proto-oncogene expression in an isolated adult rat heart. | |
| | |
MedLine Citation:
|
PMID: 3135413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Chronic cardiac overload induces quantitative and qualitative changes of the phenotype which finally adapt the myocardium to its new functional requirements (Swynghedauw, 1986). It has been proposed that both stretch and enhanced isometric tension could trigger these modifications (Peterson and Lesch, 1972), but until now no real messenger has been found. In a search for signals which may account for these changes, we decided to investigate the expression of two proto-oncogenes, c-fos and c-myc, coding for nuclear proteins (review in Adamson, 1987) because several of their properties are consistent with their possessing a role in the transduction of extracellular growth signals to the cell interior. We report here that, in adult rat heart, expression of the c-fos and c-myc proto-oncogene was both sequentially and transitorily increased when, in a beating heart but not in an arrested heart, the coronary flow (and/or pressure) was augmented. This was studied in an isolated, coronary perfused heart preparation, a model in which the initial conditions of a cardiac overload may be mimicked in such a way that protein synthesis is stimulated by increasing the coronary perfusion pressure (Kira et al., 1984). |
| | |
Authors:
|
C Bauters; J M Moalic; J Bercovici; C Mouas; R Emanoil-Ravier; S Schiaffino; B Swynghedauw |
Related Documents
:
|
10943613 - Abnormal coronary flow profiles at rest and during rapid atrial pacing in patients with... 14759083 - L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human cor... 8268533 - Development of a miniature intraventricular axial flow blood pump. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Journal of molecular and cellular cardiology Volume: 20 ISSN: 0022-2828 ISO Abbreviation: J. Mol. Cell. Cardiol. Publication Date: 1988 Feb |
Date Detail:
|
Created Date: 1988-08-30 Completed Date: 1988-08-30 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0262322 Medline TA: J Mol Cell Cardiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 97-101 Citation Subset: IM |
Affiliation:
|
U 127 INSERM, Hopital Lariboisière, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Circulation* Myocardial Contraction* Myocardium / metabolism* Perfusion Proto-Oncogene Proteins / biosynthesis* Proto-Oncogene Proteins c-fos Proto-Oncogene Proteins c-myc Rats |
| Chemical | |
Reg. No./Substance:
|
0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-fos; 0/Proto-Oncogene Proteins c-myc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Refined crystal structure of Streptomyces griseus trypsin at 1.7 A resolution.
Next Document: Influence of local intracellular pH changes on pH and action potentials in adjacent parts of cardiac...