| Coronary effects of endothelin-1 and vasopressin during acute hypotension in anesthetized goats. | |
| | |
MedLine Citation:
|
PMID: 15894011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Coronary effects of endothelin-1 and vasopressin during acute hypotension, and the role of NO and prostanoids in these effects were examined in anesthetized goats. Left circumflex coronary artery flow was measured electromagnetically, and hypotension was induced by constriction of the caudal vena cava in animals non-treated (7 goats) or treated with the inhibitor of NO synthesis N(w)-nitro-L-arginine methyl esther (L-NAME, 5 goats), the cyclooxygenase inhibitor meclofenamate (5 goats) or both drugs (5 goats). Under normotension (22 goats), mean arterial pressure averaged 93 +/- 3 mm Hg and coronary vascular conductance (CVC) 0.37 +/- 0.025 ml/min/mm Hg. Endothelin-1 (0.01-0.3 nmol) and vasopressin (0.03-1 nmol), intracoronarily injected, dose-dependently decreased CVC by up to 56% for endothelin-1 and 40% for vasopressin. During hypotension in every condition tested, mean arterial pressure decreased to approximately 60 mm Hg, and CVC only decreased during hypotension pretreated with L-NAME (23%) or L-NAME + meclofenamate (34%). Under non-treated hypotension, the decreases in CVC by endothelin-1 were augmented approximately 1.5 fold, and those by vasopressin were not modified. This increase in CVR by endothelin-1 was not affected by L-NAME and was reversed by meclofenamate or L-NAME + meclofenamate. The coronary effects of vasopressin were not modified by any of these treatments. Therefore, acute hypotension increases the coronary vasoconstriction in response to endothelin-1 but not to vasopressin. This increased response to endothelin-1 may be related to both inhibition of NO release and release of vasoconstrictor prostanoids. |
| | |
Authors:
|
Nuria Fernández; Ma Angeles Martínez; Angel Luis García-Villalón; Luis Monge; Godofredo Diéguez |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-02-19 |
Journal Detail:
|
Title: Life sciences Volume: 77 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2005 Jun |
Date Detail:
|
Created Date: 2005-05-16 Completed Date: 2005-06-17 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
|
Languages: eng Pagination: 423-34 Citation Subset: IM |
Affiliation:
|
Departamento de Fisiología, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo 2, 28029 Madrid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acute Disease Anesthesia* Animals Blood Pressure / drug effects, physiology Coronary Circulation / drug effects*, physiology Cyclooxygenase Inhibitors / pharmacology Disease Models, Animal Endothelin-1 / pharmacology* Female Goats Hypotension / metabolism, physiopathology* Meclofenamic Acid / pharmacology NG-Nitroarginine Methyl Ester / pharmacology Nitric Oxide / metabolism Vasoconstriction / drug effects*, physiology Vasopressins / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Cyclooxygenase Inhibitors; 0/Endothelin-1; 10102-43-9/Nitric Oxide; 11000-17-2/Vasopressins; 50903-99-6/NG-Nitroarginine Methyl Ester; 644-62-2/Meclofenamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increased cold allodynia following intrathecal N-methyl-D-aspartate in rats with a mononeuropathy.
Next Document: Interrelation between long-chain fatty acid oxidation rate and carnitine palmitoyltransferase 1 acti...