Document Detail


Coronary dilator effect of MCI-176, a new calcium channel blocker, in dogs.
MedLine Citation:
PMID:  3775769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of MCI-176, 2-(2,5-dimethoxyphenylmethyl)-3-(2-dimethylaminoethyl)-6-isopropox y-4 (3H)-quinazolinone hydrochloride, on coronary and aortic blood flows, mean blood pressure and heart rate were investigated in comparison with those of diltiazem in anesthetized dogs. MCI-176, like diltiazem, dose-dependently increased coronary and aortic blood flows and decreased mean blood pressure. In producing these effect MCI-176 was slightly but significantly more potent than diltiazem. Heart rate tended to increase with MCI-176, whereas it tended to decrease with diltiazem.
Authors:
D Horii; A Ishibashi
Related Documents :
1960999 - Methods of cardiac preservation alter the function of the endothelium in porcine corona...
1564919 - The coronary bed and its role in the cardiovascular system: a review and an introductor...
18258419 - Ginkgo biloba extract improves coronary blood flow in healthy elderly adults: role of e...
2924419 - Tissue acidosis: role in sustained arteriolar dilatation distal to a coronary stenosis.
7867199 - Effect of beta-adrenergic receptor blockade on blood flow to collateral-dependent myoca...
6228529 - Adenosine and metabolic regulation of coronary blood flow in dogs with renal hypertension.
2760569 - Efficacy and safety of a polyester leukocyte removal filter for whole blood and red cel...
9776289 - Noninvasive quantitation of cerebral blood flow using oxygen-15-water and a dual-pet sy...
21398649 - Aortic flow patterns resulting from right axillary artery cannulation.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  150     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-12-10     Completed Date:  1986-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  101-2     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Aorta / physiology
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Diltiazem / pharmacology
Dogs
Heart Rate / drug effects
Quinazolines / pharmacology*
Quinazolinones
Chemical
Reg. No./Substance:
0/Quinazolines; 0/Quinazolinones; 103315-31-7/MCI 176; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Serum Erythropoietin levels and inhibitors of erythropoiesis in patients with chronic renal failure.
Next Document:  Postoperative growth of the left subclavian artery in a case after a modified Blalock-Park procedure...