Document Detail

Coronary dilator effect of MCI-176, a new calcium channel blocker, in dogs.
MedLine Citation:
PMID:  3775769     Owner:  NLM     Status:  MEDLINE    
Effects of MCI-176, 2-(2,5-dimethoxyphenylmethyl)-3-(2-dimethylaminoethyl)-6-isopropox y-4 (3H)-quinazolinone hydrochloride, on coronary and aortic blood flows, mean blood pressure and heart rate were investigated in comparison with those of diltiazem in anesthetized dogs. MCI-176, like diltiazem, dose-dependently increased coronary and aortic blood flows and decreased mean blood pressure. In producing these effect MCI-176 was slightly but significantly more potent than diltiazem. Heart rate tended to increase with MCI-176, whereas it tended to decrease with diltiazem.
D Horii; A Ishibashi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  150     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-12-10     Completed Date:  1986-12-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  101-2     Citation Subset:  IM    
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MeSH Terms
Aorta / physiology
Blood Flow Velocity / drug effects
Blood Pressure / drug effects
Coronary Circulation / drug effects*
Diltiazem / pharmacology
Heart Rate / drug effects
Quinazolines / pharmacology*
Reg. No./Substance:
0/Quinazolines; 0/Quinazolinones; 103315-31-7/MCI 176; 42399-41-7/Diltiazem

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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