Document Detail

Coronary circulation and myocardial metabolism in dilated cardiomyopathy.
MedLine Citation:
PMID:  3792006     Owner:  NLM     Status:  MEDLINE    
Chest pain is a frequent complaint in patients with dilated cardiomyopathy (DCMP). Myocardial blood flow, coronary circulation parameters and coronary sinus lactate content were measured in 14 patients with DCMP and 10 healthy subjects. Myocardial blood flow in DCMP was 53.1 +/- 3.3 vs. 66.3 +/- 4.9 ml/min/100 g in the control group (p less than 0.05), coronary driving pressure was 59.1 +/- 4.6 vs. 72.8 +/- 8.8 mmHg (p less than 0.01). Subendocardial flow index (DPTI/TTI) in DCMP was 0.76 +/- 0.12 vs. 1.15 +/- 0.19 (p less than 0.01). The lactate content in coronary sinus blood was greater (1.93 +/- 0.45 mmol/l) than in the control group (1.43 +/- 0.48) (p less than 0.05). These results suggest that in DCMP myocardial blood flow is decreased, and in the majority of patients lactate is produced. Thus, it is possible that pain in DCMP is of anginal origin.
J S Dubiel; J P Dubiel; J Frendo; K Zmudka; T Horzela
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cor et vasa     Volume:  28     ISSN:  0010-8650     ISO Abbreviation:  Cor Vasa     Publication Date:  1986  
Date Detail:
Created Date:  1987-02-17     Completed Date:  1987-02-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372614     Medline TA:  Cor Vasa     Country:  CZECHOSLOVAKIA    
Other Details:
Languages:  eng     Pagination:  356-64     Citation Subset:  IM    
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MeSH Terms
Cardiomyopathy, Dilated / blood,  physiopathology*
Coronary Circulation*
Lactates / blood
Middle Aged
Myocardium / metabolism*
Oxygen / blood
Reg. No./Substance:
0/Lactates; 7782-44-7/Oxygen

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