| Coronary circulation in the failing heart. | |
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MedLine Citation:
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PMID: 9486928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In congestive heart failure, vascular resistance increases because of vasoconstriction caused by activation of the neurohumoral system. On the other hand, vasodilatory responses can partially compensate for vasoconstriction by increasing vasodilatory substances. Although vasoconstrictive forces predominate as a whole, there is heterogeneity in the responses of different vascular beds to vasoactive agents. Especially, as for coronary circulation in the setting of heart failure, many factors may cause disturbances in coronary circulation. Thus, in this review, we discuss from the point of view of neurohumoral modification of coronary flow, coronary flow reserve, endothelial dependent and independent control of vasomotor tone, vascular responses in relation to vessel size or the severity of heart disease, and mechanical factors that determine coronary circulation. Throughout these discussions, the mechanism responsible for the reduction in coronary dilatory capacity is also described. Depressed myocardial blood flow and a blunted flow response to cardiovascular stimulation together may be one important mechanism responsible for the progression of disease in patients with cardiac dysfunction. Accordingly, even though it is not known whether abnormal coronary circulation is a cause or effect of heart failure, the treatment of impaired coronary flow reserve seems to be essential in the care of patients with cardiac dysfunction. |
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Authors:
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Y Maruyama; T Saito; K Maehara |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Japanese heart journal Volume: 38 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1997 Nov |
Date Detail:
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Created Date: 1998-03-04 Completed Date: 1998-03-04 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 755-67 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Fukushima Medical College, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Volume Coronary Circulation* Heart Failure / physiopathology* Humans Neurotransmitter Agents / physiology Nitric Oxide / physiology Vascular Resistance Vasoconstriction Ventricular Pressure |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents; 10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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