Document Detail

Coronary and cardiovascular risk estimation in uncomplicated mild hypertension. A comparison of risk assessment methods.
MedLine Citation:
PMID:  12409955     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the accuracy of five risk assessment methods in identifying patients with uncomplicated mild hypertension at high coronary heart disease (CHD) and cardiovascular disease (CVD) risk.DESIGN Comparison of risk estimates using each risk assessment method with CHD risk 15% and CVD risk 20% over 10 years calculated using the Framingham risk functions. SETTING: British population. SUBJECTS: People aged 35-64 years with uncomplicated mild systolic hypertension (systolic blood pressure (SBP) 140-159 mmHg, = 202) from the 1995 Scottish Health Survey. MAIN OUTCOME MEASURES: Sensitivity, specificity, positive and negative predictive values. RESULTS: Compared with CHD risk 15% over 10 years, the Sheffield table and Joint British Societies (JBS) Chart had good sensitivity and specificity ( 90%). The New Zealand (NZ) Chart had sensitivity 83% and specificity 89%. Compared with CVD risk 20% over 10 years the Sheffield table had sensitivity 81%, the JBS Chart had sensitivity 63%, and the NZ Chart had sensitivity 75%. All had good specificity ( 90%). For CHD risk and CVD risk the World Health Organization/International Society of Hypertension (WHO-ISH) and United States Joint National Committee VI (JNC-VI) methods had high sensitivity at the cost of very poor specificity ( 50%). CONCLUSION: In patients with uncomplicated mild hypertension, the Sheffield table and JBS Chart both identified CHD risk 15% over 10 years with acceptable accuracy, while the NZ Chart was less accurate. Compared with CVD risk 20% over 10 years, these three risk assessment methods were all less accurate, but the Sheffield table retained the highest sensitivity ( 0.05 versus JBS Chart, = NS versus NZ Chart). The WHO-ISH and JNC-VI methods had unacceptably low specificities compared with both measures of risk and failed to differentiate between those at high and low risk.
Joseph I N M Yikona; Erica J Wallis; Lawrence E Ramsay; Peter R Jackson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  20     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-31     Completed Date:  2003-05-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2173-82     Citation Subset:  IM    
Clinical Pharmacology and Therapeutics, Royal Hallamshire Hospital, Gossop Road, Sheffield S10 2JF, UK.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Antilipemic Agents / therapeutic use
Aspirin / therapeutic use
Coronary Disease / drug therapy,  epidemiology*,  prevention & control
Great Britain / epidemiology
Health Status Indicators*
Hypertension / drug therapy,  epidemiology*,  prevention & control
Predictive Value of Tests
Reproducibility of Results
Risk Factors
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antilipemic Agents; 50-78-2/Aspirin
Comment In:
J Hypertens. 2002 Nov;20(11):2127-30   [PMID:  12409944 ]

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