| Coronary calcium scoring using 16-row multislice computed tomography: nonenhanced versus contrast-enhanced studies in vitro and in vivo. | |
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MedLine Citation:
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PMID: 15714089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to assess the agreement of coronary artery calcium score in nonenhanced and contrast-enhanced multislice-spiral computed tomography. MATERIALS AND METHODS: Vessel phantoms and 36 patients underwent nonenhanced and contrast-enhanced cardiac multislice-spiral computed tomography (Sensation 16; Siemens, Germany). Reconstruction-parameters: slice thickness 3 mm, increment 2 mm, kernels B35f and B30f. The Agatston score, calcium mass, and number of lesions were calculated. Images were scored using detection thresholds of 130 Hounsfield units (HU) and 350 HU. Based on the Agatston score, risk stratification was performed. RESULTS: In the phantom and patient study, altering the threshold from 130 to 350 HU led to a significant decrease in the mean Agatston score (phantom: 54.6%, patients: 66.7%) and calcium mass (33.0%, 47.0%) (B35f). Contrast-enhanced studies (threshold: 350 HU) showed an increase of the mean Agatston score (71.0%, 20.7%) and calcium mass (81.0%, 16.0%) when compared with nonenhanced scans (threshold: 350 HU). A total of 57% of all patients were assigned to different risk groups. CONCLUSIONS: Contrast material may simulate calcification; therefore, calculation of the coronary calcium score from contrast-enhanced images is not reliable. |
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Authors:
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Georg Mühlenbruch; Joachim E Wildberger; Ralf Koos; Marco Das; Thomas G Flohr; Matthias Niethammer; Claudia Weiss; Rolf W Günther; Andreas H Mahnken |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 40 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-02-16 Completed Date: 2006-02-22 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 148-54 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Radiology, University Hospital (RWTH) Aachen, Germany. gmuehlen@rad.rwth-aachen.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Calcinosis
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radiography* Calcium / analysis Calibration Cardiomyopathies / radiography* Contrast Media* / administration & dosage Coronary Artery Disease / radiography* Humans Image Processing, Computer-Assisted Iohexol / administration & dosage, analogs & derivatives* Male Middle Aged Phantoms, Imaging Tomography, Spiral Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 66108-95-0/Iohexol; 73334-07-3/iopromide; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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