Document Detail


Coronary calcium as a predictor of coronary events in four racial or ethnic groups.
MedLine Citation:
PMID:  18367736     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups. METHODS: We collected data on risk factors and performed scanning for coronary calcium in a population-based sample of 6722 men and women, of whom 38.6% were white, 27.6% were black, 21.9% were Hispanic, and 11.9% were Chinese. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 3.8 years. RESULTS: There were 162 coronary events, of which 89 were major events (myocardial infarction or death from coronary heart disease). In comparison with participants with no coronary calcium, the adjusted risk of a coronary event was increased by a factor of 7.73 among participants with coronary calcium scores between 101 and 300 and by a factor of 9.67 among participants with scores above 300 (P<0.001 for both comparisons). Among the four racial and ethnic groups, a doubling of the calcium score increased the risk of a major coronary event by 15 to 35% and the risk of any coronary event by 18 to 39%. The areas under the receiver-operating-characteristic curves for the prediction of both major coronary events and any coronary event were higher when the calcium score was added to the standard risk factors. CONCLUSIONS: The coronary calcium score is a strong predictor of incident coronary heart disease and provides predictive information beyond that provided by standard risk factors in four major racial and ethnic groups in the United States. No major differences among racial and ethnic groups in the predictive value of calcium scores were detected.
Authors:
Robert Detrano; Alan D Guerci; J Jeffrey Carr; Diane E Bild; Gregory Burke; Aaron R Folsom; Kiang Liu; Steven Shea; Moyses Szklo; David A Bluemke; Daniel H O'Leary; Russell Tracy; Karol Watson; Nathan D Wong; Richard A Kronmal
Related Documents :
21683506 - The diastolic function to cyclic variation of myocardial ultrasonic backscatter relatio...
1740936 - Use of stress thallium imaging to stratify cardiac risk in patients undergoing vascular...
9358506 - Present and future role of ambulatory holter monitoring for arrhythmia risk stratificat...
19520336 - Diagnostic and prognostic value of absence of coronary artery calcification.
811106 - Nitroglycerin in experimental myocardial infarction. effects on regional left ventricul...
23132296 - Heavy metal scavenger metallothionein mitigates deep hypothermia-induced myocardial con...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The New England journal of medicine     Volume:  358     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-27     Completed Date:  2008-04-01     Revised Date:  2009-08-14    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1336-45     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2008 Massachusetts Medical Society.
Affiliation:
Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA. robert@chinacal.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Calcinosis / ethnology,  pathology,  radiography*
Calcium / analysis*
Continental Population Groups
Coronary Angiography
Coronary Artery Disease / ethnology,  pathology,  radiography*
Coronary Disease / ethnology*
Coronary Vessels / chemistry*
Female
Follow-Up Studies
Humans
Kaplan-Meiers Estimate
Male
Middle Aged
Prognosis
Risk Assessment / methods*
Risk Factors
Severity of Illness Index
Tomography, X-Ray Computed
Grant Support
ID/Acronym/Agency:
N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95166/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7440-70-2/Calcium
Comments/Corrections
Comment In:
N Engl J Med. 2008 Jul 10;359(2):203; author reply 204   [PMID:  18618949 ]
N Engl J Med. 2008 Jul 10;359(2):202-3; author reply 204   [PMID:  18618948 ]
N Engl J Med. 2008 Mar 27;358(13):1394-6   [PMID:  18367744 ]
N Engl J Med. 2008 Jul 10;359(2):202; author reply 204   [PMID:  18618947 ]
J Am Coll Cardiol. 2009 Aug 18;54(8):745; author reply 745-6   [PMID:  19679260 ]
N Engl J Med. 2008 Jul 10;359(2):202; author reply 204   [PMID:  18614789 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Rapid disuse atrophy of diaphragm fibers in mechanically ventilated humans.
Next Document:  Cervical length at mid-pregnancy and the risk of primary cesarean delivery.