Document Detail


Coronary calcification in patients with end-stage renal disease: a novel endocrine disorder?
MedLine Citation:
PMID:  17704043     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular mortality is significantly increased among patients with end-stage renal disease. The commonly observed vascular calcification in such patients has been considered as one of the causative factors. In patients undergoing dialysis, the incidence of coronary artery calcification is 2-5 times higher compared to patients with normal renal function and angiographically demonstrated coronary artery disease. Moreover, epidemiological studies have revealed a significant correlation of the extent of coronary artery calcification with the severity of underlying atherosclerotic lesions. Vascular calcification was initially considered as a passive process of hydroxyapatite deposition due to elevated plasma concentrations of calcium and phosphate. Nevertheless, there is a growing body of evidence that vascular calcification is an actively regulated and cell-mediated process. This phenomenon includes phenotypic alterations of vascular smooth muscle cells mainly resulting from an imbalance between promoters (such as increased Ca x P product) and inhibitors (fetuin-A, GLA protein, osteoprotegerin) of mineral deposition. With regard to the therapeutic approach, despite the evident effectiveness of both traditional and innovative remedies in the management of metabolic and electrolytic abnormalities of patients with end-stage renal disease, an individualized intervention based on etiopathogenesis is really required.
Authors:
Georgios Efstratiadis; Konstantinos Koskinas; Efstathios Pagourelias
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Hormones (Athens, Greece)     Volume:  6     ISSN:  1109-3099     ISO Abbreviation:  Hormones (Athens)     Publication Date:    2007 Apr-Jun
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-09-18     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  101142469     Medline TA:  Hormones (Athens)     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  120-31     Citation Subset:  IM    
Affiliation:
Nephrology Department of Aristotle University, Thessaloniki, Greece. efstrati@med.auth.gr
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MeSH Terms
Descriptor/Qualifier:
Blood Proteins / metabolism
Calcinosis / classification,  etiology*,  therapy
Calcium / metabolism
Calcium-Binding Proteins / metabolism
Coronary Artery Disease / classification,  etiology*,  therapy
Endocrine System Diseases / classification
Extracellular Matrix Proteins / metabolism
Humans
Kidney Failure, Chronic / complications*,  metabolism
Minerals / antagonists & inhibitors,  metabolism
Muscle, Smooth, Vascular / metabolism
Myocytes, Smooth Muscle / metabolism
Osteoprotegerin / metabolism
Phosphorus / metabolism
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Calcium-Binding Proteins; 0/Extracellular Matrix Proteins; 0/Minerals; 0/Osteoprotegerin; 0/alpha2HS glycoprotein; 0/matrix Gla protein; 7440-70-2/Calcium; 7723-14-0/Phosphorus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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