Document Detail

Coronary calcification detected by electron-beam computed tomography and myocardial infarction. The Rotterdam Coronary Calcification Study.
MedLine Citation:
PMID:  12323159     Owner:  NLM     Status:  MEDLINE    
AIMS: Available data are insufficient to determine the relation between coronary calcification and coronary events in the general population. We cross-sectionally examined the association between coronary calcification and myocardial infarction in the prospective Rotterdam Coronary Calcification Study. METHODS AND RESULTS: From 1997 onwards, subjects were invited for electron-beam computed tomography scanning to detect coronary calcification. The study was embedded in the population-based Rotterdam Study. Calcifications were quantified in a calcium score according to Agatston's method. Calcium scores were available for 2,013 participants with a mean age of 71 years (standard deviation, 5.7 years). A history of myocardial infarction prior to scanning was present in 229 subjects. Compared to subjects in the lowest calcium score category (0-100), the age-adjusted odds ratio for myocardial infarction in subjects in the highest calcium score category (above 2,000) was 7.7 (95% confidence interval, 4.1-14.5) for men, and 6.7 (95% confidence interval, 2.4-19.1) for women. Additional adjustment for cardiovascular risk factors only slightly altered the estimates. The association was observed across all age subgroups, i.e. also in subjects of 70 years and older. CONCLUSION: A strong and graded association was found between coronary calcification and myocardial infarction. The association remained at high ages.
R Vliegenthart; M Oudkerk; B Song; D A M van der Kuip; A Hofman; J C M Witteman
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  23     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-26     Completed Date:  2002-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  1596-1603     Citation Subset:  IM    
Copyright Information:
Copyright 2002 The European Society of Cardiology. Published by Elsevier Science Ltd. All rights reserved.
Department of Epidemiology & Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
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MeSH Terms
Calcinosis / complications*,  radiography*
Coronary Disease / complications*,  radiography*
Cross-Sectional Studies
Middle Aged
Myocardial Infarction / etiology*
Odds Ratio
Prospective Studies
Tomography, X-Ray Computed*
Comment On:
Eur Heart J. 2002 Oct;23(20):1562-5   [PMID:  12323153 ]

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