Document Detail

Coronary calcification and cardiac events after percutaneous intervention in dialysis patients.
MedLine Citation:
PMID:  11455844     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies have described increased vascular calcification in renal dialysis patients. The clinical significance of this finding with respect to outcomes after percutaneous coronary intervention in this population is unknown. METHODS: We analysed a prospective interventional database at a single tertiary center and identified 41 dialysis patients who underwent coronary angioplasty. All studies were reviewed for the presence of coronary calcium in the target and reference vessels and compared with respect to baseline clinical factors and cardiovascular outcomes. RESULTS: The mean ages for those with and without coronary calcification were 63.6 +/- 11.0 and 67.3 +/- 11.0, respectively, P = 0.30. The groups were similar in years on dialysis, diabetes, hypertension, smoking, and measures of calcium and phosphate balance. The total cholesterol, LDL-C, HDL-C, and triglycerides were 162.5 +/- 42.3 and 202.0 +/- 54.5, P = 0.02; 94.9 +/- 39.6 and 121.2 +/- 48.1, P = 0.18; 39.3 +/- 12.4 and 47.3 +/- 12.2, P = 0.15; 157.4 +/- 100.4 and 181.3 +/- 187.4, P = 0.15, for those with and without calcification, respectively. The composite of target vessel revascularization, myocardial infarction, or death was 47.4% and 77.3% for those with and without calcification, respectively, P = 0.06. The Cox proportional hazards model, controlling for years on dialysis, showed a significant, event-free survival in those with coronary calcium seen fluoroscopically, P = 0.05. CONCLUSIONS: In dialysis patients, coronary calcification identified in the target or reference vessels is associated with lower total cholesterol and favourable interventional outcomes.
D L Bonifacio; K Malineni; R A Kadakia; S S Soman; K R Sandberg; P A McCullough
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiovascular risk     Volume:  8     ISSN:  1350-6277     ISO Abbreviation:  J Cardiovasc Risk     Publication Date:  2001 Jun 
Date Detail:
Created Date:  2001-07-17     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9436980     Medline TA:  J Cardiovasc Risk     Country:  England    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA.
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MeSH Terms
Aged, 80 and over
Angioplasty, Transluminal, Percutaneous Coronary*
Calcinosis / etiology*,  mortality
Calcium / blood
Cardiomyopathies / etiology*,  mortality
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Confidence Intervals
Coronary Vessels / pathology
Follow-Up Studies
Kidney Failure, Chronic / complications,  mortality,  therapy
Middle Aged
Potassium / blood
Renal Dialysis*
Survival Analysis
Treatment Outcome
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol; 7440-09-7/Potassium; 7440-70-2/Calcium

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