| Coronary blood flow and thallium 201 uptake in rejecting rat heart transplantations. | |
| | |
MedLine Citation:
|
PMID: 2651618 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of rejection on coronary flow (CAF) in heart allografts are unclear, although previous evidence with cardiac imaging agents indicates impaired flow during advanced rejection. The purpose of this study was to measure CAF in heterotopically placed heart grafts. Lewis rats (LEW) received grafts from either syngeneic Lewis rats (LEW/LEW group) or allogeneic ACI rats (ACI/LEW group). CAF was measured in both the transplanted and native hearts with radiolabeled microspheres. Rejection was measured histologically (grades 0 [absent] to 4+ [severe]). In addition systemic blood pressure and cardiac outputs of the native hearts were determined with microspheres. Different animals were studied during relatively early (4 days) and late (6 days) rejection. Among the 4-day animals a cyclosporine-treated group was included (ACI/LEW CyA). In 6-day rats CAF in allografts was lower (0.56 +/- .06 ml/gm/min) compared with syngeneic grafts (1.72 +/- 0.4 ml/gm/min) (p less than 0.05). The CAF in the native hearts did not differ significantly but was higher than in the grafts in both groups. Heart rates were reduced in allografts (p less than 0.05). It is interesting that arterial pressure and cardiac output were significantly lower in animals bearing allogeneic than syngeneic grafts. In rats studied at 4 days graft CAF was lower than in the native heart in both the LEW/LEW and ACI/LEW groups, but there was no significant difference in behavior between groups. The same was true for a cyclosporine-treated group. Graft heart rates were similar in all 4-day rats.(ABSTRACT TRUNCATED AT 250 WORDS) |
| | |
Authors:
|
J Bergsland; K Hwang; R Driscoll; E A Carr; J R Wright; D C Curran-Everett; M Carroll; E Krasney; J A Krasney |
Related Documents
:
|
8850388 - Effects of na(+)-h+ exchange blocker amiloride on left ventricular remodeling after ant... 14478 - Myocardial noradrenaline uptake after coronary occlusion in the rat. 14966778 - Valsartan-induced cardioprotection involves angiotensin ii type 2 receptor upregulation... 15520318 - Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contri... 3342488 - Entrainment of ventricular tachycardia: explanation for surface electrocardiographic ph... 19645848 - Methods and reliability of tissue doppler imaging for assessment of left ventricular ra... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of heart transplantation Volume: 8 ISSN: 0887-2570 ISO Abbreviation: J Heart Transplant Publication Date: 1989 Mar-Apr |
Date Detail:
|
Created Date: 1989-05-26 Completed Date: 1989-05-26 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8604172 Medline TA: J Heart Transplant Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 147-53 Citation Subset: IM |
Affiliation:
|
Department of Surgery, Veterans Administration Medical Center, Buffalo, NY 14215. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Circulation* Coronary Vessels / physiopathology* Graft Rejection* Heart / physiopathology, radionuclide imaging Heart Transplantation* Hemodynamics Immunosuppression Male Myocardium / metabolism Rats Rats, Inbred Lew Thallium Radioisotopes / diagnostic use |
| Grant Support | |
ID/Acronym/Agency:
|
HL-28542/HL/NHLBI NIH HHS; HL-36126/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Thallium Radioisotopes |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Magnetic resonance imaging of human orthotopic heart transplantation: correlation with endomyocardia...
Next Document: Coronary artery spasm in heart transplant recipients.