| Coronary blood flow reserve during +Gz stress and treadmill exercise in miniature swine. | |
| | |
MedLine Citation:
|
PMID: 3403443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The purpose of this study was to compare the coronary blood flow reserve (CBFR) that exists during maximal +Gz stress to the CBFR during maximal exercise stress. Maximal exercise stress was defined as an exercise intensity greater than or equal to that necessary to produce maximal levels of O2 consumption (VO2max). Coronary blood flows (CBF) were determined with the use of the microsphere technique in chronically instrumented conscious miniature swine during +Gz stress and exercise stress at 70 and 100% of maximal tolerance (for each stress) before and after maximal coronary vasodilation with 1-2 mg/kg dipyridamole. CBFR was measured as the amount of blood flow increase produced by maximal coronary vasodilation. During exercise at VO2max, dipyridamole produced 20-30% increases in CBF, whereas it induced no coronary vasodilation or changes in CBF during +Gz stress. Dipyridamole also produced decreases in the animals' tolerance to +Gz in that all five animals could maintain a steady state for 60 s at 7 +Gz before dipyridamole, whereas only two of these animals could maintain a steady state for 60 s at 7 +Gz after dipyridamole. These results confirm that CBFR exists during maximal exercise in normal mammals. However, this dose of dipyridamole produced no coronary vasodilation during either level of +Gz stress. |
| | |
Authors:
|
M H Laughlin; J W Burns; J Fanton; J Ripperger; D F Peterson |
Related Documents
:
|
15677423 - Psychosocial stress-induced activation of salivary alpha-amylase: an indicator of sympa... 18238363 - Integrated protective systems for operational acceleration-induced loss of consciousness. 6381543 - A comparison of relaxation training and competing response training to eliminate hair p... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 64 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1988 Jun |
Date Detail:
|
Created Date: 1988-09-21 Completed Date: 1988-09-21 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 2589-96 Citation Subset: IM; S |
Affiliation:
|
Department of Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Body Temperature Coronary Circulation* Dipyridamole / pharmacology Female Gravitation Heart Rate / drug effects Male Physical Exertion* Reference Values Stress, Physiological / physiopathology* Swine Swine, Miniature |
| Grant Support | |
ID/Acronym/Agency:
|
HL-01774/HL/NHLBI NIH HHS; HL-36531/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
58-32-2/Dipyridamole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Peripheral vascular responses to hyperthermia in the rat.
Next Document: Control of inspiratory duration in premature infants.