Document Detail

Coronary blood flow in healthy neonates: effects of left ventricular function and mass.
MedLine Citation:
PMID:  12881769     Owner:  NLM     Status:  MEDLINE    
This study used transthoracic echocardiography, including pulsed-wave Doppler, to register coronary flow parameters in 55 healthy neonates. Intraobserver variability was tested in 20 neonates. A Doppler tracing of sufficient quality for analysis was obtained in the left anterior descending coronary artery (LAD) in 53 of 55 studies (96.4% feasibility) and in the right coronary artery (RCA) in 11 of 55 studies (20.0% feasibility). Estimation of intraobserver variability showed coefficients of variation of 7.5-8.0% for diastolic LAD Doppler flow parameters and volume flow but 17.5% for systolic peak flow velocity. Doppler flow parameters were significantly higher in the LAD than in the RCA. Correlation was found between LAD Doppler flow parameters and age, left ventricular (LV) mass, mitral peak early wave velocity as a measure of diastolic LV function, and the aortic velocity time integral/minute as a measure of systolic LV function. This study shows that diastolic LAD Doppler flow parameters and flow volume can be obtained in neonates by transthoracic echocardiography with acceptable reproducibility. In healthy neonates, left coronary flow parameters are linearly related to age, LV mass, and LV systolic and diastolic function. RCA flow parameters in neonates are lower than in the LAD.
G Oskarsson; E Pesonen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-07-29
Journal Detail:
Title:  Pediatric cardiology     Volume:  25     ISSN:  0172-0643     ISO Abbreviation:  Pediatr Cardiol     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-03-24     Completed Date:  2004-04-22     Revised Date:  2008-02-20    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  11-6     Citation Subset:  IM    
Department of Pediatrics, Division of Pediatric Cardiology, University Hospital of Lund, S-22185 Lund, Sweden.
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MeSH Terms
Blood Flow Velocity
Coronary Circulation / physiology*
Coronary Vessels / physiology*
Echocardiography, Doppler
Infant, Newborn
Ventricular Function, Left / physiology

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