Document Detail

Coronary artery vasospasm causing acute myocardial infarction in a heart transplant recipient.
MedLine Citation:
PMID:  15737767     Owner:  NLM     Status:  MEDLINE    
The etiology of cardiac allograft vasculopathy is not known, but may be preceded by both endothelial cell and smooth muscle dysfunction of the epicardial coronary arteries. We here report a case of acute, reversible coronary artery vasospasm which caused a myocardial infarction in a cardiac transplant recipient. The patient had a complex post-transplant course, including an episode of severe vascular rejection several months before this presentation. Interestingly, the event was captured in its early stages because the patient presented with chest pain: a rare event because of the denervation of the transplanted heart. Our ability to document the etiology of this patient's myocardial infarction supports the concept that cardiac allograft vasculopathy is a progressive disease that, in its early stages, may include a reversible component of abnormal vasoreactivity.
John D Bisognano; Joann Lindenfeld; Elizabeth Hammond; Lawrence S Zisman
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  24     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-01     Completed Date:  2005-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  355-8     Citation Subset:  IM    
University of Rochester Medical Center, Rochester, New York, NY, USA.
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MeSH Terms
Acute Disease
Coronary Angiography
Coronary Vasospasm / complications*,  drug therapy,  epidemiology,  physiopathology
Disease Progression
Graft Rejection / epidemiology
Heart Transplantation*
Middle Aged
Myocardial Infarction / etiology*
Nitroglycerin / therapeutic use
Transplantation, Homologous
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Vasodilator Agents; 55-63-0/Nitroglycerin

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