Document Detail


Coronary artery spasm is a major cause of sudden cardiac arrest in survivors without underlying heart disease.
MedLine Citation:
PMID:  8269209     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The role of coronary spasm in underlying disease-free patients who were resuscitated from sudden cardiac arrest remained uncertain. This study investigated the cause of cardiac arrest, and the etiologic and prognostic differences were compared between patients with underlying heart disease (group I) and those patients without underlying heart disease (group II). METHODS: Twenty-five survivors of sudden cardiac arrest were classified into two groups according to the presence or absence of underlying heart disease. To investigate the cause of cardiac arrest, we performed ergonovine testing and electrophysiologic study. Fifteen of the patients had underlying heart disease, while 10 did not. RESULTS: Electrophysiologic abnormalities were found in 13 of the 15 patients in group I. In group II, spontaneous attack of coronary spasm occurred in four patients during the observation period, and coronary spasm was induced in three of the remaining six period of 32 +/- 23 months, whereas no patients in group II had recurrence of sudden cardiac arrest at a median follow-up of 32 months (range, 10 to 72 months). CONCLUSIONS: Electrophysiologic study identified a potential cause in 13 of 15 patients with underlying heart disease. Coronary spasm was involved in the pathogenesis of sudden cardiac arrest in survivors without identifiable underlying heart disease.
Authors:
Y Igarashi; Y Tamura; K Suzuki; Y Tanabe; T Yamaguchi; T Fujita; M Yamazoe; Y Aizawa; A Shibata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  4     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1994-02-01     Completed Date:  1994-02-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  177-85     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Niigata University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Cardiac Pacing, Artificial
Coronary Angiography / drug effects
Coronary Vasospasm / complications*,  diagnosis,  mortality
Death, Sudden, Cardiac / etiology*
Electrocardiography / drug effects
Female
Follow-Up Studies
Heart Arrest / etiology*,  mortality
Humans
Long QT Syndrome / complications,  mortality
Male
Methylergonovine / diagnostic use
Middle Aged
Myocardial Infarction / complications,  mortality
Wolff-Parkinson-White Syndrome / complications,  mortality
Chemical
Reg. No./Substance:
113-42-8/Methylergonovine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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