Document Detail

Coronary artery spasm during exercise: treatment with verapamil.
MedLine Citation:
PMID:  7237728     Owner:  NLM     Status:  MEDLINE    
Six patients who had documented coronary spasm and no coronary artery with organic obstruction greater than 50% developed angina and ST-segment elevation on exercise testing. Oral verapamil, 160-480 mg/day, prevented exercise-induced ischemia in all patients and increased maximal work capacity from 611+/- 250 kpm to 808 +/- 160 kpm (p less than 0.02). In two patients, a relationship between the prevention of exercise-provoked ischemia and the plasma concentration of verapamil was demonstrated, and in one of these, the relationship had a diurnal pattern. Patients with variant angina may develop coronary spasm on effort and often respond to verapamil.
B Freedman; R F Dunn; D R Richmond; D T Kelly
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  64     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1981 Jul 
Date Detail:
Created Date:  1981-08-10     Completed Date:  1981-08-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  68-75     Citation Subset:  AIM; IM    
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MeSH Terms
Angina Pectoris / etiology*
Angina Pectoris, Variant / drug therapy,  etiology*
Exercise Test
Middle Aged
Physical Exertion*
Verapamil / blood,  therapeutic use*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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