Document Detail

Coronary artery reperfusion: effects of occlusion duration on reactive hyperemia responses.
MedLine Citation:
PMID:  1079724     Owner:  NLM     Status:  MEDLINE    
In 24 unanesthetized dogs, we monitored reactive hyperemia responses in the coronary vascular bed after different durations of coronary occlusion and during coronary artery reperfusion. After two hours of occlusion, no significant changes in functional capacity occurred, evidenced by unchanged peak reactive hyperemia, reactive hyperemia flow and repayment of flow debt responses. With occlusions of six hours or more, these responses were impaired upon reperfusion, and remained diminished for up to five days. In those animals reperfused after two and six hours of coronary occlusion, myocardial infarcts were significantly smaller than those seen in animals reperfused after 24 to 72 hours of occlusion (4%, 14%, 20% and 21%, respectively). Thus, the effectiveness of any reperfusion procedure depends on its early institution when the coronary vascular bed has minimal change in functional capacity and the size of the infarct can still be reduced.
C M Bloor; F C White
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Basic research in cardiology     Volume:  70     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1975 Mar-Apr
Date Detail:
Created Date:  1975-09-04     Completed Date:  1975-09-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  148-58     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Coronary Artery Bypass
Coronary Circulation*
Coronary Disease / physiopathology*
Coronary Vessels / physiopathology*
Disease Models, Animal
Heart Rate
Hyperemia / etiology,  physiopathology*
Ischemia / complications,  physiopathology*
Myocardial Infarction / physiopathology*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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