| Coronary artery narrowing in rats: mechanical alterations of left and right myocardium. | |
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MedLine Citation:
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PMID: 1750536 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of chronic coronary artery narrowing on myocardial contractile performance, nonocclusive constriction of the left coronary artery near its origin was surgically induced in rats and global cardiac hemodynamics, left and right myocardial mechanics, and the magnitude and distribution of tissue damage and interstitial fibrosis in the left ventricular wall were analyzed 1 mo later. Reductions in coronary artery luminal diameter of 55% resulted in left ventricular failure as characterized by decreases in systemic arterial pressures, systolic ventricular pressure, rise and decay in first derivative of left ventricular pressure (+/- dP/dt), and an increase in left ventricular end-diastolic pressure. Right side dysfunction was also present as documented by an elevation in right ventricular end-diastolic pressure and a reduction in -dP/dt. In vitro measurements of papillary muscle mechanics revealed a biventricular reduction in isometric developed tension and peak rates of tension rise and decay. Moreover, the kinetic parameters of isometric contraction duration, time to peak tension and time to one-half relaxation, were significantly shorter in left muscles from coronary artery-narrowed animals. Isotonically, peak muscle shortening was reduced in the left muscle, whereas time to peak shortening was prolonged in the right myocardium. In addition, the velocities of muscle shortening and relengthening were decreased in both ventricles. Foci of replacement fibrosis and diffuse interstitial fibrosis were found in the epimyocardium, midmyocardium, and endomyocardium, demonstrating that a significant amount of myocyte loss occurred throughout the left ventricular wall.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J M Capasso; P Li; X Zhang; P Anversa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of physiology Volume: 261 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-01-23 Completed Date: 1992-01-23 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H1802-10 Citation Subset: IM |
Affiliation:
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Department of Medicine, New York Medical College, Valhalla 10595. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / etiology, pathology, physiopathology* Constriction Coronary Disease / etiology, pathology, physiopathology* Coronary Vessels Fibrosis Heart Ventricles / physiopathology Hemodynamics Kinetics Male Myocardial Contraction / physiology* Myocardium / pathology Papillary Muscles / physiopathology Rats Rats, Inbred Strains |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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