Document Detail


Coronary artery endothelial cells and microparticles increase expression of VCAM-1 in myocardial infarction.
MedLine Citation:
PMID:  25413339     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Coronary artery disease (CAD) is characterised by progressive atherosclerotic plaque leading to flow-limiting stenosis, while myocardial infarction (MI) occurs due to plaque rupture or erosion with abrupt coronary artery occlusion. Multiple inflammatory pathways influence plaque stability, but direct assessment of endothelial inflammation at the site of coronary artery stenosis has largely been limited to pathology samples or animal models of atherosclerosis. We describe a technique for isolating and characterising endothelial cells (ECs) and EC microparticles (EMPs) derived directly from the site of coronary artery plaque during balloon angioplasty and percutaneous coronary intervention. Coronary artery endothelial cells (CAECs) were identified using imaging flow cytometry (IFC), and individual CAEC and EMP expression of the pro-atherogenic adhesion molecule vascular cell adhesion molecule-1 (VCAM-1) was assessed immediately following angioplasty. Patients with MI registered 73 % higher VCAM-1 expression on their CAECs and 79 % higher expression on EMPs compared to patients with stable CAD. In contrast, VCAM-1 expression was absent on ECs in the circulation from these same subjects. VCAM-1 density was significantly higher on CAECs and EMPs among patients with MI and positively correlated with markers of myocardial infarct size. We conclude that increased VCAM-1 expression on EC and formation of EMP at the site of coronary plaque is positively correlated with the extent of vascular inflammation in patients with myocardial infarction.
Authors:
C E Radecke; A E Warrick; G D Singh; J Rogers; S I Simon; E J Armstrong
Related Documents :
14975539 - Incremental prognostic value of myocardial perfusion 99m-technetium-sestamibi spect in ...
6605729 - The impact of coronary artery disease on carotid endarterectomy.
11028479 - A common variant of the ampd1 gene predicts improved cardiovascular survival in patient...
15754849 - Increased concentrations of lipoprotein(a), circadian rhythms and metabolic reactions e...
8465739 - Identification of high-risk patients with left main and three-vessel coronary artery di...
17453539 - Differences in plaque composition and distribution in stable coronary artery disease ve...
9236429 - Intracoronary angiotensin ii potentiates coronary sympathetic vasoconstriction in humans.
17245479 - Improving outcomes in chronic heart failure.
8562899 - Safety issues regarding early extubation after coronary artery bypass surgery.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-20
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  113     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-21     Completed Date:  -     Revised Date:  2014-11-21    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multidimensional gain control in image representation and processing in vision.
Next Document:  Efficient photovoltaic and electroluminescent perovskite devices.