Document Detail

Coronary artery dynamics in vivo.
MedLine Citation:
PMID:  12085995     Owner:  NLM     Status:  MEDLINE    
There is considerable evidence that the localization and evolution of vascular disease are mediated, at least in part, by mechanical factors. The mechanical environment of the coronary arteries, which are tethered to the beating heart, is influenced by cardiac motion; the motion of the vessels must be described quantitatively to characterize fully the mechanical forces acting on and in the vessel wall. Several techniques that have been used to characterize coronary artery dynamics from biplane cineangiograms are described and illustrated. There is considerable variability in dynamic geometric parameters from site to site along a vessel, between the right and left anterior descending arteries, and among individuals, consistent with the hypotheses that variations in stresses mediated by geometry and dynamics affect the localization of atherosclerosis and individual risk of coronary heart disease. The few frankly atherosclerotic vessels that have been examined exhibit high torsions in the neighborhood of lesions, an observation which may have etiologic or diagnostic implications.
Zhaohua Ding; Hui Zhu; Morton H Friedman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of biomedical engineering     Volume:  30     ISSN:  0090-6964     ISO Abbreviation:  Ann Biomed Eng     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2003-01-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0361512     Medline TA:  Ann Biomed Eng     Country:  United States    
Other Details:
Languages:  eng     Pagination:  419-29     Citation Subset:  IM    
Department of Diagnostic Radiology, Yale University, New Haven, CT, USA.
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MeSH Terms
Arteries / physiopathology
Cineangiography / instrumentation,  methods*
Coronary Angiography / instrumentation,  methods*
Coronary Artery Disease / physiopathology*,  radiography*
Coronary Vessels / physiopathology*
Imaging, Three-Dimensional / methods*
Phantoms, Imaging
Radiographic Image Enhancement / methods
Sensitivity and Specificity
Torsion Abnormality / physiopathology,  radiography
Grant Support

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