| Coronary artery constriction caused by the cold pressor test in human hypertension. | |
| | |
MedLine Citation:
|
PMID: 8039846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hypertensive patients with angiographically normal coronary arteries may have myocardial ischemia when metabolic demand increases. Abnormal epicardial coronary artery vasomotion in response to sympathetic stimulation may contribute to ischemia in such patients. We studied the vasomotor response of smooth coronary arteries to a cold pressor test in 10 hypertensive patients without other risk factors and in 9 control subjects. Vessel dimensions were measured by quantitative angiography, and blood flow was calculated using an intracoronary Doppler catheter in the left anterior descending coronary artery. In response to cold pressor stimulation, arteries of control subjects dilated 13.0 +/- 5.9% (P < .001), and they constricted 8.2 +/- 8.5% in hypertensive patients (P < .001). Rate-pressure product increased from 9466 +/- 1677 to 12,547 +/- 2367 beats per minute (bpm).mm Hg in control subjects (P < .001) and from 13,720 +/- 1823 to 17,353 +/- 2037 bpm.mm Hg in hypertensive patients (P < .001). Coronary blood flow velocity and blood flow increased 51 +/- 26% (P < .05) and 87 +/- 27% (P < .001), respectively, in control subjects and 68 +/- 52% (P < .05) and 36 +/- 33% (P < .01) in hypertensive patients. At peak cold pressor test, despite a significant higher rate-pressure product in hypertensive patients, blood flow was similar in both groups, suggesting an uncoupling between myocardial metabolic demand and supply. Thus, hypertension impairs the vasodilator response of angiographically normal coronary arteries to a cold pressor test. This abnormal response may be due to enhanced catecholamine reactivity and/or impairment of endothelial flow-mediated vasodilator response. |
| | |
Authors:
|
I Antony; E Aptecar; G Lerebours; A Nitenberg |
Related Documents
:
|
14696166 - Pulse transmission coefficient: a nonhyperemic index for physiologic assessment of proc... 9600526 - Characteristics of coronary flow velocity in constrictive pericarditis. 3976316 - Coronary haemodynamic effects of surgery during enflurane-nitrous oxide anaesthesia in ... 21228786 - Responses of the ambulatory arterial stiffness index and other measures of arterial fun... 9595256 - Calcium antagonists in african-american patients. 20305886 - Hemodynamics and bispectral index (bis) of dogs anesthetized with midazolam and ketamin... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hypertension Volume: 24 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1994 Aug |
Date Detail:
|
Created Date: 1994-08-25 Completed Date: 1994-08-25 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 212-9 Citation Subset: IM |
Affiliation:
|
Service d'Explorations Fonctionnelles, Centre Hospitalier et Universitaire Xavier Bichat, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Cold Temperature Coronary Angiography Coronary Circulation / drug effects Coronary Vessels / physiopathology* Endothelium, Vascular / physiology Female Humans Hypertension / physiopathology* Isosorbide Dinitrate / pharmacology Male Middle Aged Sympathetic Nervous System / physiology Vasoconstriction* / drug effects |
| Chemical | |
Reg. No./Substance:
|
87-33-2/Isosorbide Dinitrate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effect of nifedipine on coronary capillary geometry in normotensive and hypertensive rats.
Next Document: Nitric oxide increases renal blood flow by interacting with the sympathetic nervous system.