Document Detail

Coronary artery changes in patients with Kawasaki disease.
MedLine Citation:
PMID:  15702674     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease (KD) is an acute, self-limiting, systemic vasculitis of unknown aetiology, which most commonly occurs in children aged 6 mo to 5 y, with a peak incidence at 9-11 mo. The inflammatory process preferentially involves the coronary arteries, potentially resulting in coronary arteritis, aneurysmal lesions, arterial thrombotic occlusion and sudden death. Kawasaki disease is the most common cause of acquired coronary vessel abnormalities in children. The cause of KD is not known, but evidence is presented for an inflammatory response and a genetic predisposition. The diagnostic tests are not yet defined, but treatment with immunoglobulin and aspirin is effective at reducing the risk of cardiac complications from 25% to 4.7% in the UK. Sequelae may occur, either acutely with myocardial, endocardial or pericardial inflammation, or many years after the original illness. There may be abnormalities of myocardial blood flow as assessed by MRI, radio-nucleide studies or echo Doppler. Such abnormalities of coronary arteries may require ongoing medication, interventional catheterization or even cardiac surgery. In the future, we hope to have more accurate diagnostic tests or prophylaxis against the disease, in addition to improved means of determining the susceptibility to or presence of long-term complications.
R M R Tulloh; L E Wood
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992). Supplement     Volume:  93     ISSN:  0803-5326     ISO Abbreviation:  Acta Paediatr Suppl     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-10     Completed Date:  2005-05-10     Revised Date:  2008-05-12    
Medline Journal Info:
Nlm Unique ID:  9315043     Medline TA:  Acta Paediatr Suppl     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Department of Congenital Heart Disease, Guy's and St. Thomas' Hospitals NHS Trust, London, United Kingdom.
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MeSH Terms
Child, Preschool
Coronary Circulation / physiology
Coronary Disease / diagnosis,  etiology,  prevention & control
Coronary Vessels / pathology*,  physiopathology*
Endothelium, Vascular / pathology,  physiopathology
Mucocutaneous Lymph Node Syndrome / diagnosis,  pathology*,  physiopathology*,  therapy

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