Document Detail

Coronary artery calcium by digital cinefluoroscopy in patients with pain suggestive of an acute coronary syndrome.
MedLine Citation:
PMID:  15757079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Detection of coronary calcium may be a useful noninvasive approach for detecting coronary artery disease (CAD) in subjects presenting to the emergency department with chest pain. HYPOTHESIS: We tried to assess the diagnostic value of coronary artery calcium (CAC) detection by digital cinefluoroscopy in patients with new-onset chest pain suggestive of an acute coronary syndrome. METHODS: In 97 consecutive patients (70 men, 27 women, mean standard deviation [SD] age 55 (11) and 60 (8) years, respectively), with new-onset chest pain suggestive of an acute coronary syndrome, nondiagnostic electrocardiogram, and normal initial creatine kinase (CK)-MB, digital cinefluoroscopy was performed for CAC detection. RESULTS: All patients underwent routine clinical evaluation with treadmill exercise test, thallium scintigraphy, dobutamine stress echocardiography, and coronary angiography, as needed clinically and blinded to the cinefluoroscopy results. Coronary artery calcium was present in 27 of 33 (81.8%) of patients with and in 10 of 64 (15.6%) of patients without CAD, p < 0.0001. The presence of CAC had 82% sensitivity, 84% specificity, 73% positive predictive value, and 90% negative predictive value for CAD diagnosis (odds ratio = 24.3, 95% confidence interval 7.98-73.94). CONCLUSIONS: In patients with acute chest pain, nondiagnostic electrocardiogram and normal initial enzyme evaluation, CAC detection by digital cinefluoroscopy appears to have high sensitivity, specificity, and negative predictive value for CAD diagnosis.
Dimitrros Alexopoulos; Christos Stathopoulos; Avraam Kotrsaridis; John Chiladakis; George Hahalis
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  Clinical cardiology     Volume:  28     ISSN:  0160-9289     ISO Abbreviation:  Clin Cardiol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-03-10     Completed Date:  2005-06-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7903272     Medline TA:  Clin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-4     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, University of Patras Medical School, Patras, Greece.
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MeSH Terms
Age Factors
Biological Markers / analysis
Calcium / analysis*
Chest Pain / radiography
Cineradiography* / methods*
Coronary Angiography / methods
Coronary Artery Disease / radiography*
Coronary Vessels / chemistry*
Middle Aged
Odds Ratio
Sensitivity and Specificity
Sex Factors
Reg. No./Substance:
0/Biological Markers; 7440-70-2/Calcium

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