Document Detail

Coronary artery calcification, arterial stiffness and renal insufficiency associate with serum levels of tumor necrosis factor-alpha in Japanese type 2 diabetic patients.
MedLine Citation:
PMID:  18573564     Owner:  NLM     Status:  MEDLINE    
Although the kidneys are the major source of proinflammatory cytokines, association of tumor necrosis factor-alpha (TNF-alpha) with severity of atherosclerosis or kidney function in diabetic patients is unclear. Two hundred type 2 diabetic patients and 30 age-matched nondiabetic subjects consecutively admitted to our hospital were enrolled. The Agatston coronary artery calcium score (CACS), a quantitative marker of coronary atherosclerosis, was obtained using multidetector-row computed tomography. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV). Diabetic patients had higher log(CACS+1) (p=0.0089), baPWV (p=0.0293), frequency of elevated urinary albumin excretion (UAE) (p<0.0001) and TNF-alpha (p=0.0029) and similar estimated glomerular filtration rate (eGFR) compared to nondiabetic subjects. When diabetic patients were grouped into four subgroups with or without elevated UAE and renal insufficiency (UAE of >/=30 or <30mg/24h and eGFR of <60 or >/=60ml/min per 1.73m(2)), patients with micro- and macroalbuminuric renal insufficiency showed the highest log(CACS+1) (p<0.0001), baPWV (p=0.0068) and TNF-alpha (p<0.0001) of these groups. Log(CACS+1) (p=0.0008) and baPWV (p=0.0006) positively and eGFR (p<0.0001) negatively correlated with TNF-alpha in diabetic patients. We find that coronary artery calcification, arterial stiffness, and renal insufficiency associate with circulating levels of TNF-alpha in type 2 diabetic patients.
Takuo Hirota; Eiji Suzuki; Isamu Ito; Masami Ishiyama; Shinobu Goto; Yukio Horikawa; Takahiko Asano; Masayuki Kanematsu; Hiroaki Hoshi; Jun Takeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-24
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  82     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  58-65     Citation Subset:  IM    
Department of Diabetes and Endocrinology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, Gifu 501-1194, Japan.
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MeSH Terms
Asian Continental Ancestry Group
Calcinosis / blood*,  pathology
Coronary Artery Disease / blood,  pathology
Diabetes Mellitus, Type 2 / blood*,  ethnology,  pathology
Glomerular Filtration Rate
Middle Aged
Renal Insufficiency / blood*,  pathology
Tomography, X-Ray Computed
Tumor Necrosis Factor-alpha / blood*
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha

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