Document Detail

Coronary artery bypass grafting is associated with a significant worsening of QT dynamicity and heart rate variability.
MedLine Citation:
PMID:  16612069     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Imbalance in autonomic nervous system and impaired myocardial repolarization has been shown to increase the risk for arrhythmias in patients with coronary artery disease. This study evaluated the effects of coronary artery bypass grafting (CABG) on heart rate variability and QT interval dynamicity in subjects with coronary artery disease undergoing elective CABG surgery. METHODS: The study group consisted of 68 consecutive patients (mean age +/-SD: 61 +/- 9 years) with coronary artery disease who underwent elective CABG. Twenty-four-hour Holter monitoring was performed 2-5 days before cardiac surgery and was repeated 10 days after CABG. ELATEC holter software was used to calculate heart rate variability and QT dynamicity parameters. All subjects had a complete history, laboratory examination and transthoracic echocardiography. RESULTS: All patients had beta-blocking agent medication pre- and postoperatively. Standard deviation of all NN intervals for a selected time period, square root of the mean of the sum of the squares of differences between adjacent RR intervals, the proportion of differences in successive NN intervals greater than 50 ms, normalized low-frequency power, and normalized high-frequency power were significantly decreased after CABG surgery, whereas low-frequency/high-frequency ratio was significantly increased after CABG. QT/RR slopes over 24 h were significantly increased after CABG surgery for QT end and QT apex (QTapex/RR: 0.16 +/- 0.13 vs. 0.28 +/- 0.19, p < 0.001; QTend/RR: 0.18 +/- 0.13 vs. 0.36 +/- 0.23, p < 0.001). CONCLUSION: This prospective study showed for the first time that CABG was associated with a significant worsening of heart rate variability and QT dynamicity parameters in the postoperative period.
Bunyamin Yavuz; Umit Duman; Gulcan Abali; Omer Faruk Dogan; Alkin Yazicioglu; Levent Sahiner; Kudret Aytemir; Lale Tokgozoglu; Metin Demircin; Nasih Nazli; Giray Kabakci; Ali Oto
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Publication Detail:
Type:  Journal Article     Date:  2006-04-10
Journal Detail:
Title:  Cardiology     Volume:  106     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-08-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  51-5     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel
Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Autonomic Nervous System / physiopathology*
Coronary Artery Bypass / adverse effects*
Coronary Disease / physiopathology*,  surgery
Electrocardiography, Ambulatory
Heart Rate / physiology*
Middle Aged
Prospective Studies
Stroke Volume / physiology
Surgical Procedures, Elective
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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