Document Detail


Coronary artery bypass graft surgery depletes plasma thiamine levels.
MedLine Citation:
PMID:  20005469     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Thiamine is an essential component of cellular metabolism, and lack of this vitamin results in a potentially life-threatening biochemical lesion. The stress of surgery and critical disease depletes electrolytes, minerals, and essential biochemical substrates. We hypothesized that critical illness (represented by major surgery) would result in decreased thiamine levels over time.
METHODS: We performed a prospective, observational study of serial thiamine levels of 15 patients who underwent non-emergent coronary artery bypass graft surgery. The primary endpoint was change in thiamine levels from before to immediately after surgery. Secondary endpoints included change in thiamine levels from presurgical to 6- and 24-h time points.
RESULTS: Of the 15 study patients, 1 did not have a plasma thiamine measurement at time 0 because of laboratory error and could not be accounted for in paired comparisons over time. Plasma thiamine levels decreased significantly from before to after coronary artery bypass grafting (P=0.0004). In addition, there was a statistically significant decrease in thiamine levels from before surgery to 24h (P=0.003).
CONCLUSION: Our data suggest that major surgery (as a surrogate for the stress of critical illness) depletes thiamine levels; further study is needed to determine whether routine replacement of thiamine in the critically ill is warranted.
Authors:
Michael W Donnino; Michael N Cocchi; Howard Smithline; Erin Carney; Peter P Chou; Justin Salciccioli; Justin Salciccoli
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  26     ISSN:  1873-1244     ISO Abbreviation:  Nutrition     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-04-05     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Bypass*
Female
Humans
Male
Middle Aged
Observation
Postoperative Complications / blood*
Prospective Studies
Thiamine / blood*
Time Factors
Grant Support
ID/Acronym/Agency:
P30 DK040561/DK/NIDDK NIH HHS; P30 DK040561-14/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
X66NSO3N35/Thiamine
Comments/Corrections
Erratum In:
Nutrition. 2011 Sep;27(9):982
Note: Salciccoli, Justin [corrected to Salciccioli, Justin]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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