Document Detail

Coronary artery and aortic valve disease as a long-term sequel of mediastinal and thoracic irradiation.
MedLine Citation:
PMID:  9089971     Owner:  NLM     Status:  MEDLINE    
Mediastinal and thoracic irradiation has been identified as a risk factor for the development of among other things, coronary artery disease (CAD) and valvular disease. We screened all patients for a history of mediastinal or thoracic radiotherapy. Between 01.07.1989 and 31.12.1995 we identified 33/16,364 patients with such a history. In 19 cases (0.12%) the cardiac disease was considered radiation-induced, nine patients were female, ten were male. Mean age was 51.7 years (range 38-73). All 19 patients displayed proximal coronary artery stenoses. Mean age in the CAD group was significantly lower (48.5, range 38-63) than in the valvular group (mean age 64.0, range 55-73). The mean interval since radiotherapy in the valvular group was significantly longer (22.25 years, range 13-32) than the one in the CAD group (12.2 years, range 7-24). All patients were treated surgically and made an uneventful recovery. Some form of mediastinal fibrosis or pericardial adhesions was present in all patients. We conclude from these findings that radiation-induced cardiac disease is infrequently encountered in patients from a large surgical center. However, especially the radiation-induced coronary artery disease displays a specific pattern of stenosis location.
G Kleikamp; U Schnepper; R Körfer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Thoracic and cardiovascular surgeon     Volume:  45     ISSN:  0171-6425     ISO Abbreviation:  Thorac Cardiovasc Surg     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-06-24     Completed Date:  1997-06-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7903387     Medline TA:  Thorac Cardiovasc Surg     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Department of Thoracic- and Cardiovascular Surgery, Nordrhein-Westfalen Heart Center, Bad Oeynhausen, Germany.
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MeSH Terms
Aortic Valve Insufficiency / etiology*,  surgery
Coronary Disease / etiology*,  surgery
Mediastinal Neoplasms / radiotherapy*
Middle Aged
Radiotherapy / adverse effects
Retrospective Studies
Risk Factors
Thoracic Neoplasms / radiotherapy*

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