Document Detail


Coronary artery aneurysms develop in weanling rabbits with serum sickness but not in mature rabbits. An experimental model for Kawasaki disease in humans.
MedLine Citation:
PMID:  7639414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The involvement of the cardiovascular system in rabbits with serum sickness is similar of that in Kawasaki disease, both with respect to the histologic changes of the myocardium, the valves, the coronary arteries, and the aorta and to the sequence with which they appear. Although coronary arteritis appears the same histologically, aneurysms did not occur in mature rabbits, even in case of necrosis of an arterial segment with deletion of muscle and elastic tissue. On the other hand, weanling rabbits with serum sickness had a tendency to develop aneurysms of coronary arteries, despite little cellular infiltration and reactive fibrocellular hyperplasia. The age factor thus appears to play an important role in the development of coronary aneurysms in Kawasaki disease, irrespective of the underlying mechanism, be it a markedly increased permeability to mediators through degenerated endothelial cells, or primary degenerated muscle cells with marked thinning of the media without much inflammatory cellular reaction. Furthermore, this study provides an insight into the long-term prognosis of transient dilatation of coronary arteries in the acute stage of Kawasaki disease.
Authors:
Z Onouchi; K Ikuta; K Nagamatsu; H Tamiya; Y Sakakibara; M Ando
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Angiology     Volume:  46     ISSN:  0003-3197     ISO Abbreviation:  Angiology     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-09-13     Completed Date:  1995-09-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0203706     Medline TA:  Angiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  679-87     Citation Subset:  IM    
Affiliation:
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Coronary Aneurysm / complications*,  pathology
Coronary Vessels / pathology
Disease Models, Animal*
Female
Humans
Male
Mucocutaneous Lymph Node Syndrome* / pathology
Myocardium / pathology
Rabbits
Serum Sickness / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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