| Coronary artery aneurysms develop in weanling rabbits with serum sickness but not in mature rabbits. An experimental model for Kawasaki disease in humans. | |
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MedLine Citation:
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PMID: 7639414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The involvement of the cardiovascular system in rabbits with serum sickness is similar of that in Kawasaki disease, both with respect to the histologic changes of the myocardium, the valves, the coronary arteries, and the aorta and to the sequence with which they appear. Although coronary arteritis appears the same histologically, aneurysms did not occur in mature rabbits, even in case of necrosis of an arterial segment with deletion of muscle and elastic tissue. On the other hand, weanling rabbits with serum sickness had a tendency to develop aneurysms of coronary arteries, despite little cellular infiltration and reactive fibrocellular hyperplasia. The age factor thus appears to play an important role in the development of coronary aneurysms in Kawasaki disease, irrespective of the underlying mechanism, be it a markedly increased permeability to mediators through degenerated endothelial cells, or primary degenerated muscle cells with marked thinning of the media without much inflammatory cellular reaction. Furthermore, this study provides an insight into the long-term prognosis of transient dilatation of coronary arteries in the acute stage of Kawasaki disease. |
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Authors:
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Z Onouchi; K Ikuta; K Nagamatsu; H Tamiya; Y Sakakibara; M Ando |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Angiology Volume: 46 ISSN: 0003-3197 ISO Abbreviation: Angiology Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-09-13 Completed Date: 1995-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0203706 Medline TA: Angiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 679-87 Citation Subset: IM |
Affiliation:
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Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Coronary Aneurysm / complications*, pathology Coronary Vessels / pathology Disease Models, Animal* Female Humans Male Mucocutaneous Lymph Node Syndrome* / pathology Myocardium / pathology Rabbits Serum Sickness / complications* |
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