Document Detail


Coronary arteriosclerosis with myocardial atrophy in a 13-year-old dog.
MedLine Citation:
PMID:  14608024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myocardial ischemia, an uncommon cause of sudden death in dogs, usually results in infarction and fibrosis of the myocardium. Necropsy examination of a 13-year-old German Shepherd dog that died suddenly demonstrated multifocal myocardial thinning and loss in the left and right ventricular free wall and right atrium. Histopathologic examination confirmed the myocardial thinning to be sites of myocyte atrophy and loss, with loose reticulin-positive fibrovascular tissue and adipocytes and little fibrosis. Many intramural coronary arteries were irregularly thickened and partially occluded by segmental intimal and medial deposits of periodic acid-Schiff-positive, Congo red-negative amorphous extracellular material. This finding is consistent with hyaline arteriosclerosis. These vascular lesions likely lead to insufficient perfusion of the affected myocardium and gradual loss of myofibers without the acute necrosis and fibrosis characteristic of infarction.
Authors:
K J Williams
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Veterinary pathology     Volume:  40     ISSN:  0300-9858     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-10     Completed Date:  2004-03-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-7     Citation Subset:  IM    
Affiliation:
Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, 210 Food Safety and Toxicology Building, Michigan State University, East Lansing, MI 48824, USA. williamsk@dcpah.msu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Atrophy
Cardiomyopathies / pathology,  veterinary*
Coronary Artery Disease / pathology,  veterinary*
Dog Diseases / pathology*
Dogs
Histological Techniques
Myocardium / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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