Document Detail


Coronary arteriography with an oxygenated contrast medium: cardiac effects in dogs with and without acute ischemic heart failure.
MedLine Citation:
PMID:  8796707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE AND OBJECTIVES: We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure. METHODS: Acute ischemic heart failure was induced by injecting small plastic microspheres into the left coronary artery of 18 dogs. Hemodynamic and electrophysiologic measurements were performed during a single injection before and during heart failure and during a single injection and five rapidly repeated CM injections during heart failure. Iohexol supplemented with electrolytes (iohexol + electrolytes = IPE), oxygenated IPE (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery. RESULTS: Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. However, repeated injections of IPE and IPE+O increased left ventricular inotropy (maximum value of the first derivative of the left ventricular pressure) by 36% and 39%, reduced heart rate by 7% (for both), and lengthened QTc time (corrected QT interval) by 39 and 38 msec, respectively. A comparison of IPE and IPE+O revealed no statistically significant differences. CONCLUSION: Although electrolyte addition to nonionic CM may reduce the risk of cardiac complications during coronary arteriography, oxygenation does not seem to significantly further reduce this risk.
Authors:
H K Pedersen; E A Jacobsen; H Refsum
Related Documents :
783197 - Effects of ouabain on myocardial oxygen supply and demand in patients with chronic coro...
7270707 - Early ischemia after complete coronary ligation in the rabbit, dog, pig, and monkey.
8097627 - Myocardial uptake and release of lactate after high dose neurolept endotracheal intubat...
7570567 - The efficacy of amrinone or adrenaline on low cardiac output following cardiopulmonary ...
17169127 - Prediction of response to cardiac resynchronization therapy: the selection of candidate...
24906987 - Black hole restenosis after drug-eluting stent implantation for in-stent restenosis: po...
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  3     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-30     Completed Date:  1996-10-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Affiliation:
Department of Radiology, University of Tromsø, Norway.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Contrast Media*
Coronary Angiography / methods*
Coronary Disease / physiopathology,  radiography*
Dogs
Electrolytes / diagnostic use
Heart Failure / physiopathology,  radiography*
Hemodynamics / physiology
Injections, Intra-Arterial
Iohexol / diagnostic use
Isotonic Solutions / diagnostic use
Myocardial Infarction / physiopathology,  radiography*
Oxygen / diagnostic use*
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Electrolytes; 0/Isotonic Solutions; 66108-95-0/Iohexol; 7782-44-7/Oxygen; 8022-63-7/Ringer's lactate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Magnetic resonance imaging detection of extraluminal enterally administered gadopentetate dimeglumin...
Next Document:  Biodistribution of cyclic carbonate of ioxilan: a radiopaque particulate macrophage imaging agent.