Document Detail

Coronary arteriography with an oxygenated contrast medium: cardiac effects in dogs with and without acute ischemic heart failure.
MedLine Citation:
PMID:  8796707     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure. METHODS: Acute ischemic heart failure was induced by injecting small plastic microspheres into the left coronary artery of 18 dogs. Hemodynamic and electrophysiologic measurements were performed during a single injection before and during heart failure and during a single injection and five rapidly repeated CM injections during heart failure. Iohexol supplemented with electrolytes (iohexol + electrolytes = IPE), oxygenated IPE (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery. RESULTS: Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. However, repeated injections of IPE and IPE+O increased left ventricular inotropy (maximum value of the first derivative of the left ventricular pressure) by 36% and 39%, reduced heart rate by 7% (for both), and lengthened QTc time (corrected QT interval) by 39 and 38 msec, respectively. A comparison of IPE and IPE+O revealed no statistically significant differences. CONCLUSION: Although electrolyte addition to nonionic CM may reduce the risk of cardiac complications during coronary arteriography, oxygenation does not seem to significantly further reduce this risk.
H K Pedersen; E A Jacobsen; H Refsum
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  3     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-10-30     Completed Date:  1996-10-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  493-9     Citation Subset:  IM    
Department of Radiology, University of Tromsø, Norway.
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MeSH Terms
Contrast Media*
Coronary Angiography / methods*
Coronary Disease / physiopathology,  radiography*
Electrolytes / diagnostic use
Heart Failure / physiopathology,  radiography*
Hemodynamics / physiology
Injections, Intra-Arterial
Iohexol / diagnostic use
Isotonic Solutions / diagnostic use
Myocardial Infarction / physiopathology,  radiography*
Oxygen / diagnostic use*
Reg. No./Substance:
0/Contrast Media; 0/Electrolytes; 0/Isotonic Solutions; 66108-95-0/Iohexol; 7782-44-7/Oxygen; 8022-63-7/Ringer's lactate

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