| Coronary arteriography with an oxygenated contrast medium: cardiac effects in dogs with and without acute ischemic heart failure. | |
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MedLine Citation:
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PMID: 8796707 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RATIONALE AND OBJECTIVES: We investigated the possible cardiac effects of oxygen addition to contrast media (CM) during coronary arteriography in dogs that did and did not have ischemic heart failure. METHODS: Acute ischemic heart failure was induced by injecting small plastic microspheres into the left coronary artery of 18 dogs. Hemodynamic and electrophysiologic measurements were performed during a single injection before and during heart failure and during a single injection and five rapidly repeated CM injections during heart failure. Iohexol supplemented with electrolytes (iohexol + electrolytes = IPE), oxygenated IPE (IPE+O), Ringer acetate, and oxygenated Ringer acetate were injected into the left coronary artery. RESULTS: Single injections of IPE and IPE+O induced small hemodynamic and electrophysiologic effects. However, repeated injections of IPE and IPE+O increased left ventricular inotropy (maximum value of the first derivative of the left ventricular pressure) by 36% and 39%, reduced heart rate by 7% (for both), and lengthened QTc time (corrected QT interval) by 39 and 38 msec, respectively. A comparison of IPE and IPE+O revealed no statistically significant differences. CONCLUSION: Although electrolyte addition to nonionic CM may reduce the risk of cardiac complications during coronary arteriography, oxygenation does not seem to significantly further reduce this risk. |
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Authors:
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H K Pedersen; E A Jacobsen; H Refsum |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Academic radiology Volume: 3 ISSN: 1076-6332 ISO Abbreviation: Acad Radiol Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-10-30 Completed Date: 1996-10-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9440159 Medline TA: Acad Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 493-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Tromsø, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Contrast Media* Coronary Angiography / methods* Coronary Disease / physiopathology, radiography* Dogs Electrolytes / diagnostic use Heart Failure / physiopathology, radiography* Hemodynamics / physiology Injections, Intra-Arterial Iohexol / diagnostic use Isotonic Solutions / diagnostic use Myocardial Infarction / physiopathology, radiography* Oxygen / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Electrolytes; 0/Isotonic Solutions; 66108-95-0/Iohexol; 7782-44-7/Oxygen; 8022-63-7/Ringer's lactate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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