Document Detail

Coronary arteries form by developmental reprogramming of venous cells.
MedLine Citation:
PMID:  20336138     Owner:  NLM     Status:  MEDLINE    
Coronary artery disease is the leading cause of death worldwide. Determining the coronary artery developmental program could aid understanding of the disease and lead to new treatments, but many aspects of the process, including their developmental origin, remain obscure. Here we show, using histological and clonal analysis in mice and cardiac organ culture, that coronary vessels arise from angiogenic sprouts of the sinus venosus-the vein that returns blood to the embryonic heart. Sprouting venous endothelial cells dedifferentiate as they migrate over and invade the myocardium. Invading cells differentiate into arteries and capillaries; cells on the surface redifferentiate into veins. These results show that some differentiated venous cells retain developmental plasticity, and indicate that position-specific cardiac signals trigger their dedifferentiation and conversion into coronary arteries, capillaries and veins. Understanding this new reprogramming process and identifying the endogenous signals should suggest more natural ways of engineering coronary bypass grafts and revascularizing the heart.
Kristy Red-Horse; Hiroo Ueno; Irving L Weissman; Mark A Krasnow
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  464     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-25     Completed Date:  2010-04-08     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  549-53     Citation Subset:  IM    
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MeSH Terms
Biological Markers / metabolism
Cell Differentiation*
Cell Lineage
Coronary Vessels / cytology*,  embryology*
Endothelial Cells / cytology
Gene Expression Regulation, Developmental
Gene Knock-In Techniques
Organ Culture Techniques
Grant Support
2T32HD007249/HD/NICHD NIH HHS; T32 HD007249/HD/NICHD NIH HHS; T32 HD007249-20/HD/NICHD NIH HHS; U01 HL099995/HL/NHLBI NIH HHS; U01 HL099999/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute
Reg. No./Substance:
0/Biological Markers
Comment In:
Nature. 2010 Mar 25;464(7288):498-9   [PMID:  20336126 ]
Nat Rev Mol Cell Biol. 2010 May;11(5):312   [PMID:  20422741 ]

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