Document Detail

Coronary arteries angiogenesis in ischemic myocardium: biocompatibility and biodegradability of various hydrogels.
MedLine Citation:
PMID:  19681839     Owner:  NLM     Status:  MEDLINE    
To evaluate the biocompatibility and biodegradability of various hydrogels and choose suitable hydrogels for the coronary arteries angiogenesis in ischemic myocardium, we synthesized six kinds of hyaluronan hydrogels, fibrin hydrogel, poly(vinyl alcohol)-chitosan hydrogel, and obtained elastin hydrogels. We examined their degradation rates and cytotoxicity in vitro. Then, hydrogels were implanted into rat adductor muscles for 1, 2, or 4 weeks. Hydrogels and surrounding tissues were resected, followed by hematoxylin and eosin staining, Masson's trichrome staining, and immunohistochemical staining for measurements of degradation, immune response, and angiogenesis. 2-Iminothiolane grafted hyaluronan hydrogel and periodate oxidated hyaluronan hydrogel presented rapid degradation rates, low quantity of inflammation-mediating cells (12 +/- 3 and 12 +/- 4 per 2.5 x 10(-3) mm(2), respectively, at week 2), thin fibrous capsules (scores were 3.8 +/- 0.1 and 4.0 +/- 0.3 per 0.33 mm(2), respectively, at week 2) with dense blood vessels in the areas surrounding the implanted hydrogels. 2-Iminothiolane grafted hyaluronan and periodate oxidated hyaluronan hydrogels with appropriate degradation rates and low immune responses were suitable for coronary arteries angiogenesis in ischemic myocardium.
Xiaodong Shen; Kuniyoshi Tanaka; Atsushi Takamori
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-07-22
Journal Detail:
Title:  Artificial organs     Volume:  33     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-23     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM    
Second Department of Surgery, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui, Japan.
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MeSH Terms
Biocompatible Materials*
Cells, Cultured
Chitosan / analogs & derivatives,  chemical synthesis
Coronary Vessels / physiopathology*
Drug Carriers
Elastin / chemistry
Fibrin / chemical synthesis
Gene Transfer Techniques
Hyaluronic Acid / chemical synthesis
Inflammation / chemically induced,  immunology
Materials Testing
Muscle, Skeletal / blood supply*,  immunology
Muscle, Smooth, Vascular / drug effects,  pathology
Myocardial Ischemia / physiopathology*
Neovascularization, Physiologic*
Pilot Projects
Polymers / chemical synthesis*,  toxicity
Polyvinyls / chemical synthesis
Rats, Sprague-Dawley
Reg. No./Substance:
0/Biocompatible Materials; 0/Drug Carriers; 0/Hydrogels; 0/Polymers; 0/Polyvinyls; 0/chitosan-g-poly(vinyl alcohol) copolymer; 9001-31-4/Fibrin; 9004-61-9/Hyaluronic Acid; 9007-58-3/Elastin; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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