| Coronary arteries angiogenesis in ischemic myocardium: biocompatibility and biodegradability of various hydrogels. | |
| | |
MedLine Citation:
|
PMID: 19681839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
To evaluate the biocompatibility and biodegradability of various hydrogels and choose suitable hydrogels for the coronary arteries angiogenesis in ischemic myocardium, we synthesized six kinds of hyaluronan hydrogels, fibrin hydrogel, poly(vinyl alcohol)-chitosan hydrogel, and obtained elastin hydrogels. We examined their degradation rates and cytotoxicity in vitro. Then, hydrogels were implanted into rat adductor muscles for 1, 2, or 4 weeks. Hydrogels and surrounding tissues were resected, followed by hematoxylin and eosin staining, Masson's trichrome staining, and immunohistochemical staining for measurements of degradation, immune response, and angiogenesis. 2-Iminothiolane grafted hyaluronan hydrogel and periodate oxidated hyaluronan hydrogel presented rapid degradation rates, low quantity of inflammation-mediating cells (12 +/- 3 and 12 +/- 4 per 2.5 x 10(-3) mm(2), respectively, at week 2), thin fibrous capsules (scores were 3.8 +/- 0.1 and 4.0 +/- 0.3 per 0.33 mm(2), respectively, at week 2) with dense blood vessels in the areas surrounding the implanted hydrogels. 2-Iminothiolane grafted hyaluronan and periodate oxidated hyaluronan hydrogels with appropriate degradation rates and low immune responses were suitable for coronary arteries angiogenesis in ischemic myocardium. |
| | |
Authors:
|
Xiaodong Shen; Kuniyoshi Tanaka; Atsushi Takamori |
Related Documents
:
|
2241659 - Computed tomographic assessment of coronary artery bypass grafts with fast dynamic scan... 19913239 - Long-term follow-up, computed tomography, and computational fluid dynamics of the cabro... 19454859 - Low-dose spironolactone: effects on artery-to-artery vein grafts and percutaneous coron... 158959 - Ultrasound of arterial graft surgery complications. 16159829 - Arterial versus venous bypass grafts in patients with in-stent restenosis. 2145959 - Clinical experience with a collagen-impregnated knitted dacron vascular graft. 11060549 - Evaluating and monitoring the adolescent with pulmonary function testing. 8495469 - Use of half of the palmaz-schatz stent in a stent-related dissection. 18044759 - Results of the multicenter first-in-man study of a novel scoring balloon catheter for t... |
Publication Detail:
|
Type: Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-22 |
Journal Detail:
|
Title: Artificial organs Volume: 33 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2009 Oct |
Date Detail:
|
Created Date: 2009-10-23 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
|
Languages: eng Pagination: 781-7 Citation Subset: IM |
Affiliation:
|
Second Department of Surgery, Faculty of Medical Sciences, University of Fukui, Yoshida-Gun, Fukui, Japan. shenxd@u-fukui.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Biocompatible Materials* Cells, Cultured Chitosan / analogs & derivatives, chemical synthesis Coronary Vessels / physiopathology* Drug Carriers Elastin / chemistry Fibrin / chemical synthesis Gene Transfer Techniques Hyaluronic Acid / chemical synthesis Hydrogels* Inflammation / chemically induced, immunology Male Materials Testing Muscle, Skeletal / blood supply*, immunology Muscle, Smooth, Vascular / drug effects, pathology Myocardial Ischemia / physiopathology* Neovascularization, Physiologic* Pilot Projects Polymers / chemical synthesis*, toxicity Polyvinyls / chemical synthesis Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Drug Carriers; 0/Hydrogels; 0/Polymers; 0/Polyvinyls; 0/chitosan-g-poly(vinyl alcohol) copolymer; 9001-31-4/Fibrin; 9004-61-9/Hyaluronic Acid; 9007-58-3/Elastin; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Extracorporeal life support as ultimate strategy for refractory severe cardiogenic shock induced by ...
Next Document: Association among serum fetuin-A level, coronary artery calcification, and bone mineral densitometry...