Document Detail

Coronary arterial stiffness is related with a loss of fractal complexity in the aortic pressure.
MedLine Citation:
PMID:  23366854     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Arterial pressure and diameter time series were evaluated in order to assess the relationship between arterial stiffness and FD.
METHODS: Three Corriedale male sheep were operated. Left anterior descending artery (LAD) was dissected and the external arterial diameter was measured trough sonomicrometry. Similarly, a pressure microtransducer was positioned in the upper third of the ascending aorta. Simultaneous pressure and diameter were measured in normal state and under smooth muscle activation. Each time series FD were assessed by the application of Higuchi's method while arterial wall elastic modulus was evaluated by means of the pressure-strain relationship.
RESULTS: Coronary stiffness was increased from normal state to phenylephrine state (47.32%, 21.12%, 10.87%) while aortic pressure FD was decreased (2.11%, 2.57%, 6.85%), respectively.
CONCLUSION: Acute hypertension induced by phenylephrine produces an increase in the coronary wall elastic modulus with a concomitant decrease in the fractal nature of the aortic pressure, suggesting that coronary stiffening is associated with an unwrinkled aortic pressure.
Leandro J Cymberknop; Walter Legnani; Franco M Pessana; Alberto Crottogini; Ricardo L Armentano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2012     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-31     Completed Date:  2013-08-02     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4200-3     Citation Subset:  IM    
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MeSH Terms
Arterial Pressure*
Computer Simulation
Coronary Artery Disease / physiopathology*
Coronary Vessels / physiopathology*
Elastic Modulus
Models, Cardiovascular*

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