| Coronary arterial reperfusion. III. Early and late effects on regional myocardial function and dimensions in conscious dogs. | |
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MedLine Citation:
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PMID: 983957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Regional myocardial function was studied in five conscious chronically instrumented dogs for 4 weeks after coronary reperfusion following a 2 hour period of occlusion of the left circumflex coronary artery. A cuff and flowmeter were placed around the left circumflex coronary artery, and a micromanometer and three pairs of ultrasonic crystals were implanted 1 cm apart subendocardially in control, marginal and ischemic segments of the left ventricle. Control normal segments showed progressive increases in end-diastolic length and extent of active shortening. Ischemic segments tended to show slight improvement early after reperfusion, but in succeeding weeks, despite some improvement in shortening, they showed progressive decreases in end-diastolic length compatible with subendocardial tissue loss. In marginally ischemic segments, shortening initially remained depressed after reperfusion, but showed late recovery so that shortening and end-diastolic length were not different from control values by 4 weeks. These results contrasted with findings in five similarly studied dogs subjected to permanent coronary occlusion; in that group the data suggested greater tissue loss and less recovery of function in marginal and ischemic segments. The late return of segmental function and reduced loss of subendocardial tissue several weeks after coronary reperfusion suggest that substantial time periods may be required to assess the ultimate effect of therapeutic interventions. The findings further indicate that in this experimental model the usual time constraints for occurrence of irreversible tissue damage do not apply to all of the myocardium within the ischemic zone. |
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Authors:
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P Theroux; J Ross; D Franklin; W S Kemper; S Sasayama |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 38 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1976 Nov |
Date Detail:
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Created Date: 1977-01-03 Completed Date: 1977-01-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 599-606 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials Animals Arrhythmias, Cardiac / physiopathology Arterial Occlusive Diseases / physiopathology Cardiac Output Cardiac Volume Coronary Circulation* Coronary Disease / physiopathology Dogs Heart Conduction System / physiopathology Heart Rate Models, Biological Myocardial Contraction* Myocardial Infarction / physiopathology Perfusion Refractory Period, Electrophysiological Tissue Survival |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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