Document Detail

Coronary angiography with multi-slice computed tomography.
MedLine Citation:
PMID:  11558487     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A new generation of subsecond multi-slice computed tomography (MSCT) scanners, which allow complete coronary coverage, are becoming widely available. We investigated the potential value of MSCT angiography in a range of coronary disorders. METHODS: We studied 35 patients, including 11 who had undergone percutaneous transluminal coronary angioplasty and four who had had coronary-artery bypass grafts, by both MSCT and conventional coronary angiography. After intravenous injection of a non-ionic contrast medium with high iodine content, the entire heart was scanned within a single breath-hold. The total examination time was no more than 20 min. The retrospective electrocardiographically gated reconstruction source images and three-dimensional reconstructed volumes were analysed by two investigators, unaware of the results of conventional angiography. FINDINGS: In the 31 patients without previous coronary surgery, 173 (73%) of the 237 proximal and middle coronary segments were assessable. In the assessable segments, 17 of 21 significant stenoses (>50% reduction of vessel diameter) were correctly diagnosed. The non-assessable segments included four lesions. Misinterpretations were mainly the result of severe calcification of the vessel wall. Segments with implanted stents were poorly visualised, but stent patency could be assessed in all cases. Of the 17 segments of bypass grafts, 15 were assessable and four of five graft lesions were detected. Two cases of anomalous coronary anatomy could be visualised well. INTERPRETATION: These preliminary data suggest that MSCT allows non-invasive imaging of coronary-artery stenoses and has potential to develop into a reliable clinical technique.
K Nieman; M Oudkerk; B J Rensing; P van Ooijen; A Munne; R J van Geuns; P J de Feyter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  357     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-09-17     Completed Date:  2001-09-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  England    
Other Details:
Languages:  eng     Pagination:  599-603     Citation Subset:  AIM; IM    
Department of Cardiology, Thoraxcenter, Rotterdam University Hospital, Netherlands.
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MeSH Terms
Coronary Angiography / methods*
Coronary Disease / diagnosis*,  pathology
Magnetic Resonance Imaging
Middle Aged
Reproducibility of Results
Retrospective Studies
Tomography, X-Ray Computed / methods*

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