Document Detail


Coronary angiographic findings and troponin T in patients with unstable angina pectoris.
MedLine Citation:
PMID:  10758918     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study sought to identify differences in coronary anatomic pathology in patients with unstable angina and elevated versus nonelevated serum troponin T values. Previous studies have shown a worse prognosis in unstable angina patients with elevated serum troponin T values. Consecutive patients (n = 117) with Braunwald class IIIB angina were included in the study. Serum samples for troponin T were obtained at admission and every 6 to 8 hours for 18 to 24 hours. Acute myocardial infarction was excluded by routine creatine kinase measurements. All patients underwent coronary angiography before discharge. Cardiac events including cardiac death and myocardial infarction were recorded. Two thirds of the patients with unstable angina had no increase in serum troponin T (<0.1 microg/L) (n = 80). They had a lower incidence of 3-vessel disease (26% vs 46%, p <0.001), left main disease (5% vs 16%, p = 0.04), visible thrombus (4% vs 22%, p = 0.006), and less severe stenosis of the culprit artery (65% vs 84%, p <0.004) than patients with elevated serum troponin T values (> or =0.1 microg/L) (n = 37). The 1-year cardiac event rate was 0% versus 19% in patients with troponin T values <0.1 microg/L compared with patients with serum troponin T values > or =0.1 microg/L (p <0.0001). It was concluded that patients with unstable angina and no release of troponin T have less severe coronary artery disease, and have an excellent prognosis. It is suggested that these patients may be managed more conservatively and without invasive evaluation before discharge.
Authors:
B Jurlander; E R Farhi; J J Banas; C M Keany; D Balu; P Grande; A K Ellis
Related Documents :
10690308 - Measurement of myocardial infarct size from plasma fatty acid-binding protein or myoglo...
21450598 - Health and cost consequences of early versus late invasive strategy after thrombolysis ...
8830618 - Measurement of serum troponin t, creatine kinase mb isoenzyme, and total creatine kinas...
15685398 - Myocardial contractile efficiency increases in proportion to a fetal enzyme shift in ch...
20522238 - Xenogeneic orthotopic heart transplantation: where are we now?
24706498 - Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infa...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  85     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-21     Completed Date:  2000-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  810-4     Citation Subset:  AIM; IM    
Affiliation:
Medical, Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Buffalo, New York, USA. bjurland@rh.dk
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Angina, Unstable / blood*,  complications,  mortality,  radiography*
Biological Markers / blood
Coronary Angiography*
Coronary Care Units
Death, Sudden, Cardiac / epidemiology,  etiology
Electrocardiography
Female
Hospital Mortality
Humans
Incidence
Male
Middle Aged
Myocardial Infarction / blood,  epidemiology,  etiology,  radiography
New York / epidemiology
Prognosis
Retrospective Studies
Troponin T / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Troponin T

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical profile and long-term prognosis of women < or = 50 years of age referred for coronary angio...
Next Document:  Heart rate variability in patients with acute myocardial infarction undergoing primary coronary angi...