Document Detail

Coronary angiographic findings and troponin T in patients with unstable angina pectoris.
MedLine Citation:
PMID:  10758918     Owner:  NLM     Status:  MEDLINE    
This study sought to identify differences in coronary anatomic pathology in patients with unstable angina and elevated versus nonelevated serum troponin T values. Previous studies have shown a worse prognosis in unstable angina patients with elevated serum troponin T values. Consecutive patients (n = 117) with Braunwald class IIIB angina were included in the study. Serum samples for troponin T were obtained at admission and every 6 to 8 hours for 18 to 24 hours. Acute myocardial infarction was excluded by routine creatine kinase measurements. All patients underwent coronary angiography before discharge. Cardiac events including cardiac death and myocardial infarction were recorded. Two thirds of the patients with unstable angina had no increase in serum troponin T (<0.1 microg/L) (n = 80). They had a lower incidence of 3-vessel disease (26% vs 46%, p <0.001), left main disease (5% vs 16%, p = 0.04), visible thrombus (4% vs 22%, p = 0.006), and less severe stenosis of the culprit artery (65% vs 84%, p <0.004) than patients with elevated serum troponin T values (> or =0.1 microg/L) (n = 37). The 1-year cardiac event rate was 0% versus 19% in patients with troponin T values <0.1 microg/L compared with patients with serum troponin T values > or =0.1 microg/L (p <0.0001). It was concluded that patients with unstable angina and no release of troponin T have less severe coronary artery disease, and have an excellent prognosis. It is suggested that these patients may be managed more conservatively and without invasive evaluation before discharge.
B Jurlander; E R Farhi; J J Banas; C M Keany; D Balu; P Grande; A K Ellis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  85     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-21     Completed Date:  2000-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  810-4     Citation Subset:  AIM; IM    
Medical, Pathology and Laboratory Medicine, Department of Veterans Affairs Medical Center, Buffalo, New York, USA.
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MeSH Terms
Aged, 80 and over
Angina, Unstable / blood*,  complications,  mortality,  radiography*
Biological Markers / blood
Coronary Angiography*
Coronary Care Units
Death, Sudden, Cardiac / epidemiology,  etiology
Hospital Mortality
Middle Aged
Myocardial Infarction / blood,  epidemiology,  etiology,  radiography
New York / epidemiology
Retrospective Studies
Troponin T / blood*
Reg. No./Substance:
0/Biological Markers; 0/Troponin T

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