Document Detail


Coronary anaphylaxis in vitro.
MedLine Citation:
PMID:  497526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 The reactivity of isolated coronary arteries and cardiac veins of the calf to selected chemical mediators of anaphylaxis and to sensitizing antigen (horse plasma) was studied. 2 Both the coronary arteries and cardiac veins contracted to bradykinin, 5-hydroxytryptamine (5-HT), prostaglandin E2 (PGE2), PGF2 alpha, histamine and carbachol. 3 Isoprenaline and PGE1 relaxed vessels which had been partially contracted by PGF2 alpha, PGE2, histamine, 5-HT, bradykinin, carbachol or antigen. 4 Horse plasma (antigen) contracted coronary vessels obtained from sensitized calves, but not from control calves. Subsequent antigen 'challenge' produced 'densensitization' (tachphylaxis). After 1 or 2 h of rest, the anaphylactic response partially recovered although there was no change in tissue reactivity to the exogenous agonists. 5 Specific doses of atropine, mepyramine (H1-blocker) and methysergide (5-HT antagonist) did not modify the anaphylactic reaction in coronary arteries, suggesting a negligible role for these biogenic amines. 6 Compound PRD-92-EA (a new anti-allergic agent) exhibited non-specific receptor blocking activity towards histamine, 5-HT and carbachol and inhibited the coronary anaphylactic reaction.
Authors:
N Chand; P Eyre
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  67     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1979 Oct 
Date Detail:
Created Date:  1980-01-28     Completed Date:  1980-01-28     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis / immunology*
Animals
Atropine / pharmacology
Carbachol / pharmacology
Cattle
Coronary Vessels / immunology*
Histamine / pharmacology
Male
Methysergide / pharmacology
Muscle Contraction / drug effects
Muscle, Smooth / drug effects
Pyrilamine / pharmacology
Serotonin / pharmacology
Chemical
Reg. No./Substance:
361-37-5/Methysergide; 50-67-9/Serotonin; 51-45-6/Histamine; 51-55-8/Atropine; 51-83-2/Carbachol; 91-84-9/Pyrilamine
Comments/Corrections

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