| Coronary MR angiography using citrate-coated very small superparamagnetic iron oxide particles as blood-pool contrast agent: initial experience in humans. | |
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MedLine Citation:
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PMID: 21769977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate very small superparamagnetic iron oxide particles (VSOP-C184) as blood-pool contrast agent for coronary MR angiography (CMRA) in humans. MATERIALS AND METHODS: Six healthy volunteers and 14 patients with suspected coronary artery disease underwent CMRA after administration of VSOP-C184 at the following doses: 20 μmol Fe/kg (4 patients), 40 μmol Fe/kg (5 patients), 45 μmol Fe/kg (6 healthy volunteers), and 60 μmol Fe/kg (5 patients). In healthy volunteers, contrast-to-noise ratio (CNR), signal-to-noise ratio (SNR), and vessel edge definition (VED) of contrast-enhanced CMRA were compared with non-contrast-enhanced CMRA. In patients, a per-segment intention-to-diagnose evaluation of contrast-enhanced CMRA for detection of significant coronary stenosis (≥50%) was performed. RESULTS: Three healthy volunteers (45 μmol Fe/kg VSOP-C184) and two patients (60 μmol Fe/kg VSOP-C184) had adverse events of mild or moderate intensity. VSOP-C184 significantly increased CNR (15.1 ± 4.6 versus 6.9 ± 1.9; P = 0.010), SNR (21.7 ± 5.3 versus 15.4 ± 1.6; P = 0.048), and VED (2.3 ± 0.6 versus 1.2 ± 0.2; P < 0.001) compared with non-contrast-enhanced CMRA. In patients, contrast-enhanced CMRA yielded sensitivity, specificity, and diagnostic accuracy for detection of significant coronary stenosis of 86.7%, 71.0%, 73.1%, respectively. CONCLUSION: CMRA using VSOP-C184 was feasible and yielded moderate diagnostic accuracy for detection of significant coronary stenosis within this proof-of-concept setting. |
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Authors:
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Moritz Wagner; Susanne Wagner; Jörg Schnorr; Eyk Schellenberger; Dietmar Kivelitz; Lasse Krug; Marc Dewey; Michael Laule; Bernd Hamm; Matthias Taupitz |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2011-07-18 |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 34 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-19 Completed Date: 2012-02-02 Revised Date: 2013-04-11 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 816-23 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley-Liss, Inc. |
Affiliation:
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Department of Radiology, Charité - Universitätsmedizin Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Case-Control Studies Contrast Media / diagnostic use Coronary Angiography / methods* Coronary Stenosis / diagnosis, radiography* Dextrans / diagnostic use* Female Ferumoxytol / diagnostic use* Humans Image Processing, Computer-Assisted Magnetic Resonance Angiography / methods* Magnetite Nanoparticles / diagnostic use* Male Middle Aged Radiographic Image Enhancement* Reference Values Reproducibility of Results Severity of Illness Index Signal-To-Noise Ratio |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Magnetite Nanoparticles; 0/superparamagnetic blood pool agent; 1317-61-9/Ferumoxytol; 9004-54-0/Dextrans; G6N3J05W84/ferumoxides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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