Document Detail

Coronary CT angiography versus intravascular ultrasound for estimation of coronary stenosis and atherosclerotic plaque burden: A meta-analysis.
MedLine Citation:
PMID:  24148779     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Numerous studies have compared coronary CT angiography (CTA) with quantitativecoronary angiography. However, the ability of coronary CTA to identify atherosclerosis and to accurately measure plaque and coronary area and volume measurements as compared with intravascular ultrasound (IVUS) has not been fully defined.
OBJECTIVE: We sought to assess the ability of coronary CTA to quantify coronary and plaque measurements commonly performed with IVUS.
METHODS: We searched multiple databases for diagnostic studies that directly compared coronary CTA and IVUS for coronary plaque detection, vessel luminal area, percentage of area stenosis, plaque area, and plaque volume. We used a bivariate mixed-effects binomial regression model to pool test sensitivity and specificity for detection of any coronary plaque.
RESULTS: Forty-two studies that evaluated 1360 patients (75% men; mean age, 59 years) were identified. No significant difference was found between coronary CTA and IVUS measurements of vessel lumen cross-sectional area, plaque area, percentage of area stenosis, or plaque volume within the overall cohort and no difference for the measurement of cross-sectional area (n = 5 studies) and plaque volume (n = 8 studies) among a subgroup that used automated or semiautomated measurement techniques. Sensitivity and specificity of coronary CTA to detect any plaque compared with IVUS were 93% and 92%, respectively, with an area under the receiver-operating curve of 0.97.
CONCLUSIONS: Compared with IVUS, coronary CTA appears to be highly accurate for estimation of luminal area, percentage of area stenosis, plaque volume, and plaque area and for detection of plaque. The use of automated vessel and stenosis measurements appears promising in limited studies to date.
Collin Fischer; Edward Hulten; Pallavi Belur; Ryan Smith; Szilard Voros; Todd C Villines
Related Documents :
23910889 - Acute myocardial ischemia monitoring before and during angioplasty by a novel vectorcar...
25323729 - Age-associated murine cardiac lesions are attenuated by the mitochondria-targeted antio...
23108779 - Coronary ct angiography and high-risk plaque morphology.
24363079 - Diagnosis of dementia with lewy bodies: diagnostic performance of combined (123)i-imp b...
21740909 - Adult human heart slices are a multicellular system suitable for electrophysiological a...
23460449 - Coronary collateral circulation-its relevance.
9972899 - Adult respiratory distress syndrome following cardiopulmonary bypass: incidence, prophy...
9584299 - Is the atrial high rate episode diagnostic feature reliable in detecting paroxysmal epi...
2534139 - Overview of hemodynamic and non-hemodynamic factors associated with left ventricular hy...
Publication Detail:
Type:  Journal Article     Date:  2013-08-23
Journal Detail:
Title:  Journal of cardiovascular computed tomography     Volume:  7     ISSN:  1876-861X     ISO Abbreviation:  J Cardiovasc Comput Tomogr     Publication Date:    2013 Jul-Aug
Date Detail:
Created Date:  2013-10-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308347     Medline TA:  J Cardiovasc Comput Tomogr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  256-66     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Cardiology Service, Dwight D. Eisenhower Army Medical Center, 300 Hospital Road, Fort Gordon, GA 30905. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Multidetector CT predictors of prosthesis-patient mismatch in transcatheter aortic valve replacement...
Next Document:  The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.