Document Detail


Coronary Artery Patency and Survival in Clinical Trials.
MedLine Citation:
PMID:  10639265     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Central to many of the major advances seen in the treatment of acute myocardial infarction over the last 15 years has been the concept that reperfusion by thrombolytic therapy, by producing early patency of an infarct-related artery, salvages myocardium and preserves left ventricular function. Large clinical trials have confirmed the mortality benefits of thrombolytic therapy, which has become the standard worldwide treatment. It is increasingly evident that complete reperfusion (TIMI 3 flow) is needed to achieve the optimum patient outcome. In addition, the benefits of microvascular reperfusion are now being recognized. The evaluation of new regimens and therapies to improve early patency are exciting current developments. Recently it has been shown for the first time that late patency of the infarct-related artery is an independent predictor of survival. This extension of the open-artery theory has major implications for both the treatment of acute myocardial infarction and future thrombolytic and revascularization policies for surviving patients.
Authors:
Ellis; French; White
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  4     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  1997  
Date Detail:
Created Date:  2000-01-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  239-250     Citation Subset:  -    
Affiliation:
Cardiology Department, Green Lane Hospital, Auckland, New Zealand.
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