Document Detail

Coronary artery disease in systemic lupus erythematosus: risk factors, assessment, and prevention.
MedLine Citation:
PMID:  19078188     Owner:  NLM     Status:  In-Data-Review    
The 10-year survival rate of patients with systemic lupus erythematosus (SLE) currently is more than 85|X%; the greater longevity permits late complications to emerge. Recent studies have shown an increased incidence of coronary artery disease (CAD), frequently in young adults. CAD currently is among the most common causes of death in patients with SLE who survive longer than 5 years. Multiple risk factors, some specific to SLE, are implicated in premature development of CAD. These include coronary artery vasculitis, hypertension and hyperlipidemia, corticosteroid therapy, and antiphospholipid antibodies, which may result in coronary thrombotic events. Therefore, risk factors for CAD should be actively sought as part of routine care of patients with SLE, and appropriate modification strategies, including medications if necessary, should be employed. Noninvasive cardiac tests should be used early in the evaluation of any symptoms consistent with myocardial ischemia, heart failure, or cardiac arrhythmias.
P J Hashkes; L F Wexler; M H Passo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  3     ISSN:  1076-1608     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  1997 Aug 
Date Detail:
Created Date:  2008-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-10     Citation Subset:  -    
William S Rowe Division of Pediatric Rheumatology, Children's Hospital Medical Center; Department of Pediatrics (P.J.H.. M.H.P), and Cardiology Section, Department of Veterans Affairs Medical Center; Department of Medicine (L.F.W.), University of Cincinnati, Cincinnati, Ohio.
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