Document Detail


Coronal in vivo forward-imaging of rat brain morphology with an ultra-small optical coherence tomography fiber probe.
MedLine Citation:
PMID:  23318277     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A well-established navigation method is one of the key conditions for successful brain surgery: it should be accurate, safe and online operable. Recent research shows that optical coherence tomography (OCT) is a potential solution for this application by providing a high resolution and small probe dimension. In this study a fiber-based spectral-domain OCT system utilizing a super-luminescent-diode with the center wavelength of 840 nm providing 14.5 μm axial resolution was used. A composite 125 μm diameter detecting probe with a gradient index (GRIN) fiber fused to a single mode fiber was employed. Signals were reconstructed into grayscale images by horizontally aligning A-scans from the same trajectory with different depths. The reconstructed images can display brain morphology along the entire trajectory. For scans of typical white matter, the signals showed a higher reflection of light intensity with lower penetration depth as well as a steeper attenuation rate compared to the scans typical for gray matter. Micro-structures such as axon bundles (70 μm) in the caudate nucleus are visible in the reconstructed images. This study explores the potential of OCT to be a navigation modality in brain surgery.
Authors:
Yijing Xie; Tim Bonin; Susanne Löffler; Gereon Hüttmann; Volker Tronnier; Ulrich G Hofmann
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Publication Detail:
Type:  Journal Article     Date:  2013-01-14
Journal Detail:
Title:  Physics in medicine and biology     Volume:  58     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  555-68     Citation Subset:  IM    
Affiliation:
Institute for Signal Processing, University of Luebeck, Luebeck, D-23562, Germany. Graduate School for Computing in Medicine and Life Sciences, University of Luebeck, Luebeck, D-23562, Germany. Neuroelectronic Systems, Department for Neurosurgery, University Medical Center Freiburg, Freiburg, D-79106, Germany.
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