| Coronal in vivo forward-imaging of rat brain morphology with an ultra-small optical coherence tomography fiber probe. | |
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MedLine Citation:
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PMID: 23318277 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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A well-established navigation method is one of the key conditions for successful brain surgery: it should be accurate, safe and online operable. Recent research shows that optical coherence tomography (OCT) is a potential solution for this application by providing a high resolution and small probe dimension. In this study a fiber-based spectral-domain OCT system utilizing a super-luminescent-diode with the center wavelength of 840 nm providing 14.5 μm axial resolution was used. A composite 125 μm diameter detecting probe with a gradient index (GRIN) fiber fused to a single mode fiber was employed. Signals were reconstructed into grayscale images by horizontally aligning A-scans from the same trajectory with different depths. The reconstructed images can display brain morphology along the entire trajectory. For scans of typical white matter, the signals showed a higher reflection of light intensity with lower penetration depth as well as a steeper attenuation rate compared to the scans typical for gray matter. Micro-structures such as axon bundles (70 μm) in the caudate nucleus are visible in the reconstructed images. This study explores the potential of OCT to be a navigation modality in brain surgery. |
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Authors:
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Yijing Xie; Tim Bonin; Susanne Löffler; Gereon Hüttmann; Volker Tronnier; Ulrich G Hofmann |
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Publication Detail:
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Type: Journal Article Date: 2013-01-14 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 58 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-01-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 555-68 Citation Subset: IM |
Affiliation:
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Institute for Signal Processing, University of Luebeck, Luebeck, D-23562, Germany. Graduate School for Computing in Medicine and Life Sciences, University of Luebeck, Luebeck, D-23562, Germany. Neuroelectronic Systems, Department for Neurosurgery, University Medical Center Freiburg, Freiburg, D-79106, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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