| Corneal ulceration in south-east Asia III: prevention of fungal keratitis at the village level in south India using topical antibiotics. | |
| | |
MedLine Citation:
|
PMID: 16916874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
AIM: To determine whether topical antifungal prophylaxis distributed by paid village health workers (VHWs) in south India is necessary after corneal abrasion to prevent fungal keratitis in a population where half of the ulcers are fungal. METHODS: Two panchayaths (village administrative units in Madurai district with a combined population of 48 039 were followed prospectively for 18 months by 15 VHWs who were trained to identify post-traumatic corneal abrasions. Patients fulfilling the eligibility criteria were randomised into two groups and treated with either 1% chloramphenicol and 1% clotrimazole ointment or 1% chloramphenicol and a placebo ointment three times a day for 3 days. Patients, doctors and VHWs were blinded to treatment. RESULTS: During the 18-month period, 1365 people reported to VHWs with ocular injuries, of whom 374 with corneal abrasions were eligible for treatment. Of these, 368 (98.5%) abrasions healed without complications. Two patients had mild localised allergic reactions to the ointment, two dropped out and two patients in the placebo group developed microscopic culture-negative corneal stromal infiltrates that healed in 1 week with natamycin drops. CONCLUSIONS: Both fungal and bacterial ulcers that occur after traumatic corneal abrasions seem to be effectively prevented in a village setting using only antibiotic prophylaxis. |
| | |
Authors:
|
M Srinivasan; M P Upadhyay; B Priyadarsini; R Mahalakshmi; J P Whitcher |
Related Documents
:
|
19821164 - Effect of anterior chamber air bubble on prevention of experimental staphylococcus epid... 17396704 - One-year outcomes of aqualase cataract surgery. 15316794 - Corneal sensation after laser epithelial keratomileusis for the correction of myopia. 9209994 - Risk factors, complications, and results in extracapsular cataract extraction. 15664094 - Evaluation of continuous infusion of 0.5% bupivacaine by elastomeric pump for postopera... 21632994 - Sonographic evaluation of femoral trochlear cartilage in patients with knee pain. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2006-08-17 |
Journal Detail:
|
Title: The British journal of ophthalmology Volume: 90 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2006-11-20 Completed Date: 2006-12-11 Revised Date: 2013-06-07 |
Medline Journal Info:
|
Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
|
Languages: eng Pagination: 1472-5 Citation Subset: IM |
Affiliation:
|
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Age Distribution Aged Antifungal Agents / therapeutic use* Child Chloramphenicol / therapeutic use Clotrimazole / therapeutic use Community Health Workers Cornea / injuries Corneal Ulcer / etiology, prevention & control* Double-Blind Method Drug Combinations Eye Infections, Fungal / etiology, prevention & control* Female Follow-Up Studies Humans India Male Middle Aged Ointments Prospective Studies Sex Distribution |
| Chemical | |
Reg. No./Substance:
|
0/Antifungal Agents; 0/Drug Combinations; 0/Ointments; 23593-75-1/Clotrimazole; 56-75-7/Chloramphenicol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Accuracy and performance of a commercially available Dosing Aid.
Next Document: Intrafamilial phenotypic variability in families with RDS mutations: exclusion of ROM1 as a genetic ...