Document Detail

Corneal thickness in ocular hypertension, primary open-angle glaucoma, and normal tension glaucoma.
MedLine Citation:
PMID:  9930155     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the effect of central corneal thickness (CCT) on the measurement of intraocular pressure (IOP) and on the resultant reclassification of patients as having primary open-angle glaucoma (POAG), normal tension glaucoma (NTG), or ocular hypertension (OHT). METHODS: Intraocular pressure (Goldmann applanation tonomety) and CCT (ultrasound pachymetry) were measured in 22 patients with NTG, 49 with POAG, 44 with OHT and in 18 control subjects. The CCT was used to obtain a corrected value for the IOP and to reclassify the type of glaucoma. RESULTS: There was no significant difference in CCT between controls (552 +/- 35 microns) and patients with POAG (543 +/- 35 microns), but the CCT in the group with NTG (521 +/- 31 microns) was significantly lower than that in the control group or the group with POAG (P < .001), and the CCT in the group with OHT (583 +/- 34 microns) was significantly higher than in controls or patients with POAG (P < .001). Correcting IOP for corneal thickness, 31% of the patients with NTG could be reclassified as having POAG, and 56% of the patients with OHT as normal. CONCLUSIONS: Patients with NTG have a thinner CCT than do patients with POAG or controls. Underestimation of the IOP in patients with POAG who have thin corneas may lead to a misdiagnosis of NTG, while overestimation of the IOP in normal subjects who have thick corneas may lead to a misdiagnosis of OHT.
R P Copt; R Thomas; A Mermoud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of ophthalmology     Volume:  117     ISSN:  0003-9950     ISO Abbreviation:  Arch. Ophthalmol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-08     Completed Date:  1999-02-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7706534     Medline TA:  Arch Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  14-6     Citation Subset:  AIM; IM    
Hôpital Ophtalmique Jules Gonin, University of Lausanne, Switzerland.
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MeSH Terms
Cornea / pathology*,  ultrasonography
Glaucoma, Open-Angle / diagnosis*
Intraocular Pressure*
Middle Aged
Ocular Hypertension / diagnosis*
Comment In:
Arch Ophthalmol. 1999 Jan;117(1):104-5   [PMID:  9930168 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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