| Corneal sensitivity in diabetic patients subjected to retinal laser photocoagulation. | |
| | |
MedLine Citation:
|
PMID: 21447686 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Purpose: To determine the changes in corneal sensitivity to different stimulus modalities in diabetes mellitus type 1 (DM1) or type 2 patients (DM2) with retinopathy, and to explore whether argon laser photocoagulation aggravates sensitivity loss in diabetic patients. Methods: Corneal sensitivity to different modalities of stimulus was determined in one randomized eye of 52 patients with DM1 (n=35) or DM2 (n=17), and of 27 healthy subjects. Medical history was obtained from all the patients, including age, gender, time from DM diagnosis, type of diabetes, time from onset of retinopathy, type of diabetic retinopathy, and type of argon laser treatment. Corneal sensitivity was determined using the Belmonte gas esthesiometer. Mechanical, chemical, heat and cold stimuli were applied on the central cornea. Results: Sensitivity thresholds to selective mechanical, chemical and cold stimulation were significantly higher in DM patients compared to controls. Sensitivity threshold to mechanical and chemical stimuli was higher in DM2 than in DM1 patients. In DM1 patients, mechanical threshold increased with time after DM diagnosis. No correlation was found between sensitivity thresholds to chemical or thermal stimulation and the age of patient, type of retinopathy, or its time from diagnosis. Laser treatment generated a further impairment of corneal sensitivity. Conclusions: Corneal sensitivity to mechanical, chemical and thermal stimulation is decreased in DM patients, suggesting that diabetes affects homogeneously the different types of sensory neurons innervating the cornea. Corneal sensitivity appears to be more disturbed in DM2 than in DM1. Laser treatment of DM patients generates a further impairment in corneal sensitivity, probably as the result of physical damage to ciliary nerves. |
| | |
Authors:
|
Waldir Neira-Zalentein; Juha M Holopainen; Timo M T Tervo; Fernando Borrás; M Carmen Acosta; Carlos Belmonte; Juana Gallar |
Related Documents
:
|
11103296 - Consumption of black tea elicits an increase in plasma antioxidant potential in humans. 8410356 - Enhanced insulin-dependent glucose utilization in iron-deficient veal calves. 17651516 - Evaluation of a compartmental model to describe non-esterified fatty acid kinetics in h... 10907836 - The effect of the plasma glucose level on the abomasal function in dairy cows. 17586746 - Muscle-strengthening activity and its association with insulin sensitivity. 4700486 - Metabolism of proinsulin, insulin, and c-peptide in the rat. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-29 |
Journal Detail:
|
Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-3-30 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, Sant Joan d'Alacant, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of suppression in amblyopia.
Next Document: Sustained antibiotic release from an intraocular lens-hydrogel assembly for cataract surgery.