Document Detail

Corneal recovery after lasik for high myopia: a 2-year prospective confocal microscopic study.
MedLine Citation:
PMID:  18650214     Owner:  NLM     Status:  MEDLINE    
AIM: To quantify human corneal recovery after moderate to high myopic laser in situ keratomileusis (LASIK) in a 2-year prospective follow-up study. METHODS: Fifteen eyes of 15 patients (mean refraction -10.1 (SD 2.4) D) were examined preoperatively and postoperatively at day 1, 5 days, 2 weeks, 1, 3 and 6 months and 2 years. Biomicroscopy, visual acuity and refraction were examined prior to imaging studies. An in vivo tandem scanning confocal microscope was used to obtain images from the central cornea. Subbasal nerve density was measured as the total length of nerve trunks in confocal image per mm2. Keratocyte density was calculated manually from stromal sublayers. The thickness of the altered keratocyte zone was measured on both sides of the LASIK interface. RESULTS: At the end of the follow-up, all patients had a 20/20 BCVA, and nine of 15 patients were within +/-0.5 D of the intended correction. The total corneal thickness remained unaltered, but epithelial hyperplasia was seen at 2 years. Keratocyte density in the anterior stroma and posterior to the flap interface showed a slight decrease during the follow-up. Subbasal nerve density decreased 82% in 5 days after LASIK. A gradual increase was observed from 2 weeks postoperatively, but even 2 years after the operation the nerve density was only 64% from the preoperative values. CONCLUSIONS: Subbasal nerve fibre density shows a gradual recovery throughout the follow-up. However, only three subjects showed totally regenerated subbasal nerve fibres at 2 years. This may correlate with the observed decrease in the density of the most anterior keratocytes. Corneal remodelling seemed to continue for at least 2 years.
J A O Moilanen; J M Holopainen; M H Vesaluoma; T M T Tervo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-23
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  92     ISSN:  1468-2079     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-25     Completed Date:  2008-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1397-402     Citation Subset:  IM    
Helsinki University Central Hospital, Department of Ophthalmology, Helsinki, Finland.
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MeSH Terms
Corneal Stroma / innervation,  surgery*
Follow-Up Studies
Keratomileusis, Laser In Situ / methods*
Microscopy, Confocal
Middle Aged
Myopia / rehabilitation,  surgery*
Nerve Fibers / physiology
Nerve Regeneration / physiology
Postoperative Period
Prospective Studies
Recovery of Function*
Treatment Outcome
Visual Acuity / physiology
Wound Healing / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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