| Corneal pharmacodynamics after photorefractive keratectomy and laser in situ keratomileusis in rabbits. | |
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MedLine Citation:
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PMID: 12046889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate changes in corneal pharmacodynamics after PRK and LASIK in rabbits. METHODS: Two groups of five rabbits (10 eyes) each received PRK and LASIK, and an unoperated third group was used as a control. Dexamethasone, efflumidex, diclofenac, and tobramycin were applied. Anterior chamber aqueous was collected every 20 minutes and analyzed by spectrophotometry. Histological studies were performed to find drug deposits in the cornea. RESULTS: The coefficient of diffusion after PRK was determined for dexamethasone (3.2 x 10(-4) cm/min), efflumidex (1.4 x 10(-4)), diclofenac (7.4 x 10(-5)), and tobramycin (5.4 x 10(-6)). After LASIK, the coefficient of diffusion for dexamethasone was 3.4 x 10(-5); efflumidex, 1.7 x 10(-5); diclofenac, 8.8 x 10(-6); and tobramycin, 2.4 x 10(-6) cm/min. Total time of passing through the cornea after PRK and LASIK was also measured: dexamethasone 45 and 70 min, efflumidex 50 and 115 min, diclofenac 60 and 200 min, and tobramycin 335 and 690 min. Histologically a drug deposit area was found in corneas after LASIK under the flap. In the control group, coefficient of diffusion for dexamethasone was 1.2 x 10(-5) cm/min, efflumidex 1.5 x 10(-5), diclofenac 6.4 x 10(-6), and tobramycin 2.1 x 10(-6). Total time of passing through the cornea for the control group for dexamethasone was 60 min, efflumidex 105 min, diclofenac 160 min, and tobramycin 540 min. CONCLUSIONS: Coefficient of diffusion increased after photorefractive surgery. |
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Authors:
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Dmitri Maitchouk; Elena Smirennaia; Vyacheslav Kourenkov |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of refractive surgery (Thorofare, N.J. : 1995) Volume: 18 ISSN: 1081-597X ISO Abbreviation: J Refract Surg Publication Date: 2002 May-Jun |
Date Detail:
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Created Date: 2002-06-05 Completed Date: 2002-12-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9505927 Medline TA: J Refract Surg Country: United States |
Other Details:
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Languages: eng Pagination: S382-4 Citation Subset: IM |
Affiliation:
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New Line Vision, Moscow, Russia. nlvision@online.ru |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacokinetics, pharmacology Anti-Inflammatory Agents / pharmacokinetics, pharmacology Anti-Inflammatory Agents, Non-Steroidal / pharmacokinetics, pharmacology Aqueous Humor / metabolism Cornea / drug effects, metabolism*, surgery* Dexamethasone / pharmacokinetics*, pharmacology Diclofenac / pharmacokinetics*, pharmacology Fluorophotometry Keratomileusis, Laser In Situ* Lasers, Excimer Ophthalmic Solutions / pharmacokinetics, pharmacology Photorefractive Keratectomy* Rabbits Tobramycin / pharmacokinetics*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Ophthalmic Solutions; 15307-86-5/Diclofenac; 32986-56-4/Tobramycin; 50-02-2/Dexamethasone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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